Liu Yang, Abulimiti Nijiati, Wang Chong
Bone Tumor Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P.R. China.
Bone Tumor Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, P.R. China
Ann Clin Lab Sci. 2018 May;48(3):338-344.
Some studies have demonstrated that the collagen triple helix repeat containing 1 (CTHRC1) protein is abnormally expressed in multiple human solid tumors. We assessed the expression of CTHRC1 in osteosarcoma.
The CTHRC1 expression status was examined by immunohistochemistry and quantitative real-time polymerase chain reaction. Then, we analyzed the relationship between CTHRC1 expression and clinicopathological characteristics in osteosarcoma patients.
The expression rate of CTHRC1 protein in osteosarcoma was significantly higher than that in adjacent normal tissues. The high expression of CTHRC1 was strongly correlated with the differentiation, recurrence rate, chemotherapy response, and metastasis in patients with osteosarcoma. The survival analysis suggested that high expression of CTHRC1 in osteosarcoma patients correlates with a shorter survival time. Cox regression analysis demonstrated that the prognosis of osteosarcoma patients was closely associated with CTHRC1.
The high CTHRC1 expression indicates the poor prognosis of osteosarcoma patients.
一些研究表明，含1型胶原蛋白三螺旋重复序列（CTHRC1）蛋白在多种人类实体瘤中异常表达。我们评估了CTHRC1在骨肉瘤中的表达情况。
采用免疫组织化学和定量实时聚合酶链反应检测CTHRC1的表达状态。然后，我们分析了骨肉瘤患者中CTHRC1表达与临床病理特征之间的关系。
骨肉瘤中CTHRC1蛋白的表达率显著高于相邻正常组织。CTHRC1的高表达与骨肉瘤患者的分化程度、复发率、化疗反应和转移密切相关。生存分析表明，骨肉瘤患者中CTHRC1的高表达与较短的生存时间相关。Cox回归分析表明，骨肉瘤患者的预后与CTHRC1密切相关。
CTHRC1的高表达表明骨肉瘤患者预后不良。
