Yamashita Kimihiro, Arimoto Akira, Nishi Masayasu, Tanaka Tomoko, Fujita Mitsugu, Fukuoka Eiji, Sugita Yutaka, Nakagawa Akio, Hasegawa Hiroshi, Suzuki Satoshi, Kakeji Yoshihiro
Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Anticancer Res. 2018 Jul;38(7):4233-4239. doi: 10.21873/anticanres.12719.
In tumor immunity, invariant natural killer T (iNKT) cells play a pivotal role as a link between the innate and adaptive immune systems. With a precisely regulated activation mechanism, iNKT cells have the ability to respond quickly to antigenic stimulation and rapidly produce cytokines and chemokines, and subsequently an effective antitumor immune response. The development of iNKT cell-targeted active immunotherapy enables, not only an antitumor immune response through innate and acquired immunity, but also the conversion of an immunosuppressive into an immunogenic microenvironment. This review is focused on the activation mechanism and the role of iNKT cells after therapeutic active immunization. The therapeutic strategy targeting iNKT cells is expected to be applied to clinical practice in combination with surgery and chemotherapy.
在肿瘤免疫中，不变自然杀伤T（iNKT）细胞作为先天性和适应性免疫系统之间的联系发挥着关键作用。iNKT细胞具有精确调控的激活机制，能够快速对抗抗原刺激做出反应，迅速产生细胞因子和趋化因子，进而引发有效的抗肿瘤免疫反应。靶向iNKT细胞的主动免疫疗法的发展，不仅能够通过先天性和获得性免疫产生抗肿瘤免疫反应，还能将免疫抑制性微环境转化为免疫原性微环境。本综述聚焦于治疗性主动免疫接种后iNKT细胞的激活机制及其作用。靶向iNKT细胞的治疗策略有望与手术和化疗联合应用于临床实践。
