Rotstein C, Cummings K M, Tidings J, Killion K, Powell E, Gustafson T L, Higby D
Infect Control. 1985 Sep;6(9):347-55. doi: 10.1017/s019594170006330x.
Between April 1982 and March 1983, 10 of 26 (38.4%) allogeneic bone marrow transplant recipients housed on a newly opened bone marrow transplant unit developed invasive aspergillosis. By contrast, between September 1977 and March 1982, only 3 of 46 (6%) transplant recipients developed invasive aspergillosis. A case-control study to identify host factors related to Aspergillus infection found that aspergillosis was more common in patients with chronic myelogenous leukemia and aplastic anemia, older patients, patients having cytomegalovirus disease, patients who experienced prolonged granulocytopenia, patients conditioned with ara-C (100-200 mg/day), and patients who received longer duration of antimicrobial therapy. A series of logistic regression analyses revealed that underlying disease was the single best predictor of Aspergillus infection. This study demonstrates that underlying disease is an important risk factor for aspergillosis and that special measures may be warranted when transplanting certain patients.
1982年4月至1983年3月期间，新启用的骨髓移植病房收治的26名异基因骨髓移植受者中有10名（38.4%）发生了侵袭性曲霉病。相比之下，1977年9月至1982年3月期间，46名移植受者中只有3名（6%）发生了侵袭性曲霉病。一项旨在确定与曲霉感染相关宿主因素的病例对照研究发现，曲霉病在慢性粒细胞白血病和再生障碍性贫血患者、老年患者、患有巨细胞病毒病的患者、粒细胞缺乏持续时间较长的患者、接受阿糖胞苷（100 - 200毫克/天）预处理的患者以及接受抗菌治疗时间较长的患者中更为常见。一系列逻辑回归分析显示，基础疾病是曲霉感染的唯一最佳预测因素。这项研究表明，基础疾病是曲霉病的一个重要危险因素，在移植某些患者时可能需要采取特殊措施。
