Wang Zhong-Yang, Li Hong-Yan, Jiang Zong-Pei, Zhou Tian-Biao
Department of Urology Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China.
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou, China.
J Cancer Res Ther. 2018 Jun;14(Supplement):S375-S380. doi: 10.4103/0973-1482.171366.
Investigations on the relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and prostate cancer risk are conflicting. This meta-analysis was conducted to assess the relationship between ACE I/D gene polymorphism and prostate cancer risk.
Reports were identified from PubMed, Cochrane Library, and China Biological Medicine (CBM)-disc (CBM database) on December 30, 2014, and eligible studies were recruited.
ACE I/D gene polymorphism was not associated with prostate cancer risk for overall populations in this meta-analysis (D allele: Odds ratio [OR] =1.56, 95% confidence interval [95% CI]: 1.00-2.46, P = 0.05; DD genotype: OR = 1.74, 95% CI: 0.95-3.20, P = 0.07; II genotype: OR = 0.67, 95% CI: 0.39-1.15, P = 0.15). Furthermore, the association of ACE I/D gene polymorphism with colorectal cancer risk was not found for the Caucasians. Interestingly, ACE I/D gene polymorphism was associated with prostate cancer risk for the Asian population and Latino population.
There was an association between ACE I/D gene polymorphism and prostate cancer risk for the Asians and Latino population in this meta-analysis. However, more investigations should be performed to confirm this relationship.
关于血管紧张素转换酶（ACE）插入/缺失（I/D）基因多态性与前列腺癌风险之间关系的研究结果相互矛盾。本荟萃分析旨在评估ACE I/D基因多态性与前列腺癌风险之间的关系。
于2014年12月30日从PubMed、考克兰图书馆和中国生物医学文献数据库（CBMdisc）中检索相关报告，并纳入符合条件的研究。
在本荟萃分析中，ACE I/D基因多态性与总体人群的前列腺癌风险无关（D等位基因：比值比[OR]=1.56，95%置信区间[95%CI]：1.00 - 2.46，P = 0.05；DD基因型：OR = 1.74，95%CI：0.95 - 3.20，P = 0.07；II基因型：OR = 0.67，95%CI：0.39 - 1.15，P = 0.15）。此外，未发现ACE I/D基因多态性与白种人的结直肠癌风险有关。有趣的是，ACE I/D基因多态性与亚洲人群和拉丁裔人群的前列腺癌风险有关。
在本荟萃分析中，ACE I/D基因多态性与亚洲人和拉丁裔人群的前列腺癌风险之间存在关联。然而，需要进行更多研究来证实这种关系。
