使用GINsim 3.0对细胞调控网络进行逻辑建模与分析。

Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0.

作者信息

Naldi Aurélien, Hernandez Céline, Abou-Jaoudé Wassim, Monteiro Pedro T, Chaouiya Claudine, Thieffry Denis

机构信息

Computational Systems Biology Team, Institut de Biologie de l'Ecole Normale Supérieure (IBENS), École Normale Supérieure, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Médicale, PSL Université, Paris, France.

INESC-ID, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal.

出版信息

Front Physiol. 2018 Jun 19;9:646. doi: 10.3389/fphys.2018.00646. eCollection 2018.

The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.