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使用GINsim 3.0对细胞调控网络进行逻辑建模与分析。

Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0.

作者信息

Naldi Aurélien, Hernandez Céline, Abou-Jaoudé Wassim, Monteiro Pedro T, Chaouiya Claudine, Thieffry Denis

机构信息

Computational Systems Biology Team, Institut de Biologie de l'Ecole Normale Supérieure (IBENS), École Normale Supérieure, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Médicale, PSL Université, Paris, France.

INESC-ID, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal.

出版信息

Front Physiol. 2018 Jun 19;9:646. doi: 10.3389/fphys.2018.00646. eCollection 2018.

DOI:10.3389/fphys.2018.00646
PMID:29971008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6018412/
Abstract

The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.

摘要

逻辑形式体系非常适合对大型细胞网络进行建模，尤其是在详细的动力学数据稀缺时。本教程聚焦于这个成熟的定性框架。依靠GINsim（3.0版）这一实现该形式体系的软件，我们逐步引导读者对哺乳动物p53-Mdm2网络的四节点模型进行定义、分析和模拟。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/6018412/38138e25731a/fphys-09-00646-g0012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/6018412/46ed1a4b976f/fphys-09-00646-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/6018412/e667c6f5d43d/fphys-09-00646-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/6018412/2577fbcc8442/fphys-09-00646-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/6018412/a454c9a06fe5/fphys-09-00646-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/beed/6018412/3a2f1d891725/fphys-09-00646-g0010.jpg
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