器官移植中的生物标志物和药物基因组学。
Biomarkers and Pharmacogenomics in Kidney Transplantation.
机构信息
Renal Department, Royal Stoke University Hospital, Stoke-on-Trent, UK.
Renal Department, Royal Shrewsbury Hospital, Shrewsbury, Shropshire, UK.
出版信息
Mol Diagn Ther. 2018 Oct;22(5):537-550. doi: 10.1007/s40291-018-0349-5.
This review is focused on present and future biomarkers, along with pharmacogenomics used in clinical practice for kidney transplantation. It aims to highlight biomarkers that could potentially be used to improve kidney transplant early and long-term graft survival, but also potentially patient co-morbidity. Future directions for improving outcomes are discussed, which include immune tolerance and personalising immunosuppression regimens.
本篇综述专注于当前和未来的生物标志物，以及在肾脏移植临床实践中使用的药物基因组学。其旨在强调潜在可用于改善肾脏移植早期和长期移植物存活率，同时也可能改善患者合并症的生物标志物。讨论了改善预后的未来方向，包括免疫耐受和个体化免疫抑制方案。
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