Liu Kun, Liu Xuzhong, Gu Shuo, Sun Qing, Wang Yunyan, Meng Junsong, Xu Zongyuan
Department of Urology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, 223300 China.
Oncotarget. 2017 Jul 24;8(37):62463-62469. doi: 10.18632/oncotarget.19516. eCollection 2017 Sep 22.
Epidemiological studies have investigated the role of transforming growth factor-β1 (TGF-β1) in chronic allograft dysfunction (CAD) following kidney transplantation. gene polymorphisms (SNP rs1800470 and rs1800471) may be associated with the risk of CAD. In this meta-analysis, the relationship between these two variations and the risk of CAD was explored.
MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), Embase, the Chinese CNKI and WANFANG databases were searched. Data were extracted and pooled results were estimated from odds ratios (ORs) with 95% confidential intervals (95% CIs). Quality assessments were performed, and publication bias of all eligible studies examined.
Eight studies with 1038 subjects were included in our analysis. According to the effects on TGF-β1 secretion, haplotypes were categorized as "HIGH", "INTERMEDIATE" and "LOW". The combined results showed a statistically significant difference of haplotypes between the CAD recipients and control subjects when "HIGH" with "INTERMEDIATE" and "LOW" ("HIGH" vs. "INTERMEDIATE" + "LOW": OR: 3.56, 95% CIs: 2.20, 5.78, P < 0.001) were compared. No significant association was found between the codon 10 or codon 25 and the CAD risk in all five genetic models.
Our meta-analysis has found the haplotype of codon 10/25 T/T G/G and T/C G/G genotypes, associated with increased production of TGF-β1, was linked with CAD risk following kidney transplantation. Moreover, no significant difference was found between TGFB1 codon 10 or codon 25 and the development of CAD.
流行病学研究调查了转化生长因子-β1（TGF-β1）在肾移植后慢性移植物功能障碍（CAD）中的作用。基因多态性（单核苷酸多态性rs1800470和rs1800471）可能与CAD风险相关。在这项荟萃分析中，探讨了这两种变异与CAD风险之间的关系。
检索了MEDLINE、EMBASE、Cochrane对照试验中央注册库（CENTRAL）、Embase、中国知网和万方数据库。提取数据并根据比值比（OR）及95%置信区间（95%CI）估计合并结果。进行质量评估，并检查所有符合条件研究的发表偏倚。
我们的分析纳入了8项研究，共1038名受试者。根据对TGF-β1分泌的影响，单倍型被分为“高”、“中”和“低”。当比较“高”与“中”和“低”（“高”vs.“中”+“低”：OR：3.56，95%CI：2.20，5.78，P<0.001）时，CAD受者与对照受试者之间单倍型存在统计学显著差异。在所有五种遗传模型中，未发现密码子10或密码子25与CAD风险之间存在显著关联。
我们的荟萃分析发现，与TGF-β1产生增加相关的密码子10/25 T/T G/G和T/C G/G基因型单倍型与肾移植后CAD风险相关。此外，未发现TGFB1密码子10或密码子25与CAD发生之间存在显著差异。
