Lender M, Verner E, Stankiewicz H, Menczel J
Gerontology. 1977;23(1):31-6. doi: 10.1159/000212171.
The intestinal absorption of 47Ca was studied in elderly patients. A standard dose of 10 muCi of 47Ca was given orally. The radioactivity was measured in the plasma, and expressed as percentage of the administered dose per litre plasma. As a control group served 12 patients aged 60-80 years, hospitalized for observation for various reasons, receiving no medical treatment and not suffering from any known metabolic bone diseases or other metabolic pathological conditions. Results of kinetic curves demonstrate in elderly patients a decreased absorption with maximum specific activity in plasma reached at 120 min, when compared to data from the literature referring to a group of young people with a mean age of 35 years. Oestrogen treatment, given as ethinyl oestradiol 10 mug once daily per os for 10 days proved to increase 47Ca absorption as was demonstrated in 2 patients with osteoporosis. The effect of calcitonin (160 MRC units given 45 min before the test) on calcium absorption, in 5 patients with Paget's disease or osteoporosis appears as biphasic: in the first hour depressing calcium absorption and then in the second and third hours increasing the absorption, suggesting a hyperparathyroid state secondary to the calcitonin effect. The vitamin D2 treatment proved to increase calcium absorption.
对老年患者的47Ca肠道吸收情况进行了研究。口服给予10微居里的标准剂量47Ca。测量血浆中的放射性，并表示为每升血浆中给药剂量的百分比。作为对照组的是12名年龄在60至80岁之间因各种原因住院观察的患者，他们未接受治疗，也未患有任何已知的代谢性骨病或其他代谢性病理状况。动力学曲线结果表明，与文献中一组平均年龄为35岁的年轻人的数据相比，老年患者的吸收减少，血浆中最大比活性在120分钟时达到。在2名骨质疏松症患者中，以每天口服10微克炔雌醇的方式进行雌激素治疗10天，结果证明可增加47Ca的吸收。在5名患有佩吉特病或骨质疏松症的患者中，降钙素（在试验前45分钟给予160 MRC单位）对钙吸收的影响呈双相：在第一小时降低钙吸收，然后在第二和第三小时增加吸收，提示降钙素作用继发甲状旁腺功能亢进状态。维生素D2治疗证明可增加钙吸收。
