Spencer H, Kramer L, Wiatrowski E, Lender M
Isr J Med Sci. 1984 May;20(5):373-80.
Multiple forms of treatment are used for osteoporosis, Paget's disease of the bone, and osteogenesis imperfecta. Because of the effect of fluoride (F) on bone, these bone conditions may benefit from F therapy. In the present study, the metabolic effects of two dose levels of F (20 and 45 mg, given as sodium fluoride) were studied on calcium (Ca) and F metabolism in patients with osteoporosis, whereas the effect of the 45-mg dose was studied in patients with Paget's disease. In patients with osteoporosis, the retention of F increased with increasing F intake, indicating F deposition in bone. However, only the 45-mg dose decreased urinary Ca excretion. F did not decrease fecal Ca excretion, indicating that the intestinal absorption of Ca did not improve during F therapy. This was confirmed in 47Ca absorption studies. The duration of F therapy was 3 months, utilizing the 45-mg dose. Clinically, the patients experienced relief of bone pain, and the onset of this change coincided with the decrease in urinary Ca. The 3-month course of treatment was sufficient for alleviation of clinical symptoms for many months and even years. In patients with Paget's disease, F supplements decreased urinary Ca and also resulted in relief of bone pain. F therapy for osteogenesis imperfecta resulted in decreased fracture incidence.
多种治疗方法用于骨质疏松症、佩吉特骨病和成骨不全症。由于氟（F）对骨骼的作用，这些骨病可能从氟治疗中获益。在本研究中，研究了两种剂量水平的氟（20毫克和45毫克，以氟化钠形式给药）对骨质疏松症患者钙（Ca）和氟代谢的代谢影响，而在佩吉特骨病患者中研究了45毫克剂量的效果。在骨质疏松症患者中，氟的潴留随着氟摄入量的增加而增加，表明氟在骨骼中沉积。然而，只有45毫克剂量降低了尿钙排泄。氟并没有降低粪钙排泄，这表明在氟治疗期间钙的肠道吸收没有改善。这在47Ca吸收研究中得到了证实。氟治疗的持续时间为3个月，采用45毫克剂量。临床上，患者的骨痛得到缓解，这种变化的出现与尿钙的减少同时发生。3个月的疗程足以缓解临床症状数月甚至数年。在佩吉特骨病患者中，补充氟减少了尿钙，也缓解了骨痛。成骨不全症的氟治疗导致骨折发生率降低。
