糖酵解圈外人走进癌症聚光灯下。
A Glycolysis Outsider Steps into the Cancer Spotlight.
机构信息
Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
出版信息
Cell Metab. 2018 Jul 3;28(1):3-4. doi: 10.1016/j.cmet.2018.06.017.
Glycolysis is prudently regulated and coupled to cell growth. Phosphofructokinase 2 controls glycolytic flux by generating fructose 2,6-bisphosphate, an allosteric activator of phosphofructokinase 1. In a recent paper in Nature, Dasgupta et al. address the novel role of PFKFB4, an isoform of phosphofructokinase 2, in regulating gene expression to promote tumor growth.
糖酵解受到谨慎调控并与细胞生长偶联。磷酸果糖激酶 2 通过生成果糖 2,6-二磷酸来控制糖酵解通量，果糖 2,6-二磷酸是磷酸果糖激酶 1 的别构激活剂。在最近发表在《自然》杂志上的一篇论文中，Dasgupta 等人研究了磷酸果糖激酶 2 的同工型 PFKFB4 在调节基因表达以促进肿瘤生长方面的新作用。
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