Gießen-Jung Clemens, von Baumgarten Louisa
Dtsch Med Wochenschr. 2018 Jul;113(13):970-978. doi: 10.1055/s-0043-120839. Epub 2018 Jul 4.
Chemotherapy-induced peripheral neuropathy (CIPN) is a severe and common side effect induced by a variety of anticancer drugs. CIPN presents as a sensory, motor, and sometimes autonomic dysfunction with a large variability, from a mild tingling sensation and hyperesthesia, to severe neuropathic pain. Up to 40 % of patients will develop CIPN which may lead to dose-reduction or discontinuation of their current treatment and largely affects their quality of life (QoL). This review presents specific clinical features and pathomechanisms and discusses current preventive strategies and therapeutic options.
化疗引起的周围神经病变（CIPN）是由多种抗癌药物引起的一种严重且常见的副作用。CIPN表现为感觉、运动功能障碍，有时还伴有自主神经功能障碍，其症状差异很大，从轻微的刺痛感和感觉过敏到严重的神经性疼痛。高达40%的患者会发生CIPN，这可能导致当前治疗方案的剂量减少或停药，并在很大程度上影响他们的生活质量（QoL）。本综述介绍了CIPN的具体临床特征和发病机制，并讨论了当前的预防策略和治疗选择。
