Erkan Turan Kadriye, Cankaya Ali Bulent, Taylan Sekeroglu Hande, Inam Onur, Karahan Sevilay
1 Department of Ophthalmology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
2 Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Eur J Ophthalmol. 2018 Jul;28(4):454-458. doi: 10.1177/1120672117747019. Epub 2018 Mar 15.
To evaluate macular pigment optical density in healthy children and to compare the values with those of strabismic children with respect to fixation preference.
The study recruited 54 healthy and 41 strabismic children. Two groups were matched in terms of gestational age, birth weight, and body mass index. All participants underwent complete ophthalmological evaluation and macular pigment optical density measurement and filled a self-reported food frequency questionnaire. Strabismic children were categorized according to fixation preference.
The mean age was 9.87 ± 2.39 years in healthy children and 9.07 ± 2.07 years in children with strabismus (p = 0.091). Mean macular pigment optical density was 0.23 ± 0.25 in healthy eyes and 0.25 ± 0.27 in non-preferred eyes of strabismic children (p = 0.964). Macular pigment optical density was significantly higher in preferred eyes of strabismic children (0.43 ± 0.34) compared to non-preferred eyes (p = 0.004) and healthy eyes (p = 0.001). There was a difference of macular pigment optical density between both eyes in patients with grades 1, 2, and 3 fixation preference, whereas patients with grade 4 preference had similar macular pigment optical density in both eyes (p = 0.008). There was a statistically significant positive correlation between macular pigment optical density in preferred eyes and body mass index (r = 0.354, p = 0.023).
Preferred eyes of children with strabismus seem to have higher macular pigment optical density readings. This difference may emerge from the higher tendency of recognizing the flicker stimulus while preferred eye is under testing. Similar macular pigment optical density in healthy and non-preferred eyes and the fact that both lower than preferred eyes remain unexplained. It should be kept in mind that macular pigment optical density results should be carefully interpreted and macular pigment optical density in cases with strabismus should be further investigated.
评估健康儿童的黄斑色素光密度，并比较斜视儿童根据注视偏好的黄斑色素光密度值。
该研究招募了54名健康儿童和41名斜视儿童。两组在胎龄、出生体重和体重指数方面进行了匹配。所有参与者均接受了全面的眼科评估和黄斑色素光密度测量，并填写了一份自我报告的食物频率问卷。斜视儿童根据注视偏好进行分类。
健康儿童的平均年龄为9.87±2.39岁，斜视儿童的平均年龄为9.07±2.07岁（p = 0.091）。健康眼的平均黄斑色素光密度为0.23±0.25，斜视儿童非优势眼的平均黄斑色素光密度为0.25±0.27（p = 0.964）。与非优势眼（p = 0.004）和健康眼（p = 0.001）相比，斜视儿童优势眼的黄斑色素光密度显著更高（0.43±0.34）。1级、2级和3级注视偏好的患者双眼黄斑色素光密度存在差异，而4级偏好的患者双眼黄斑色素光密度相似（p = 0.008）。优势眼黄斑色素光密度与体重指数之间存在统计学显著正相关（r = 0.354，p = 0.023）。
斜视儿童的优势眼似乎具有更高的黄斑色素光密度读数。这种差异可能源于在测试优势眼时识别闪烁刺激的较高倾向。健康眼和非优势眼黄斑色素光密度相似，且两者均低于优势眼这一事实仍无法解释。应牢记，黄斑色素光密度结果应谨慎解读，斜视病例中的黄斑色素光密度应进一步研究。
