a Department of pharmaceutics, Faculty of Pharmacy , Zagazig University , Zagazig , Egypt.
b Department of Pharmacology, Faculty of Medicine , El-Fayoum University , El-Fayoum , Egypt.
Drug Dev Ind Pharm. 2018 Nov;44(11):1797-1808. doi: 10.1080/03639045.2018.1496449. Epub 2018 Sep 3.
To develop an alternative medicine, propolis, in emulgel formulation for burn and wound treatment.
The effect of two independent variables: emulsifying agent concentration and oil concentration on the cumulative amount of propolis release (dependent variable) from liquid paraffin and isopropyl palmitate emulgels was investigated. Eight formulations were prepared and evaluated for physical appearance, pH, propolis content, viscosity, and in vitro propolis release. The release results were fitted into different kinetic equations and analyzed using contour plot, interaction surface plot and one-way ANOVA. The selected emulgel formulation was investigated for its wound and burn healing activity in rats.
All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, and pH value. The concentration of emulsifying agent had more pronounced effect on propolis release than oil concentration. Formulations F1-F6 showed "anomalous" drug release, while Formulations F7 and F8 showed zero-order kinetic.
The formulation F7 with 5% isopropyl palmitate, 5% emulsifier mixture, 1% hydroxyl propyl methyl cellulose, 1% oleic acid, and 10% propylene glycol is a promising formula for better management of wound and burn.
开发一种替代医学药物——蜂胶，以乳凝胶制剂的形式用于烧伤和创伤治疗。
考察两种独立变量（乳化剂浓度和油浓度）对液体石蜡和异丙基肉豆蔻酸酯乳凝胶中蜂胶累积释放量（因变量）的影响。制备了 8 种制剂，并对其外观、pH 值、蜂胶含量、粘度和体外蜂胶释放进行了评价。释放结果被拟合到不同的动力学方程中，并通过轮廓图、相互作用表面图和单因素方差分析进行了分析。选择的乳凝胶制剂用于研究其在大鼠中的创伤和烧伤愈合活性。
所有制备的乳凝胶在颜色、均匀性、一致性和 pH 值方面均表现出可接受的物理性质。乳化剂浓度对蜂胶释放的影响比油浓度更为显著。制剂 F1-F6 显示出“异常”的药物释放，而制剂 F7 和 F8 显示出零级动力学。
含有 5%异丙基肉豆蔻酸酯、5%乳化剂混合物、1%羟丙基甲基纤维素、1%油酸和 10%丙二醇的 F7 制剂是一种有前途的配方，可以更好地管理创伤和烧伤。
Zotero 插件