Abe Miyuki, Saburi Masuho, Itani Kazuhito, Kohno Kazuhiro, Soga Yasuhiro, Kondo Yoshiyuki, Kawano Yawara, Nakayama Toshiyuki
Department of Hematology, Oita Kouseiren Tsurumi Hospital.
Department of Hematology, Nishibeppu National Hospital.
Rinsho Ketsueki. 2018;59(6):695-697. doi: 10.11406/rinketsu.59.695.
A 76-year-old woman presented to our hospital with leukocytosis and abnormal lymphocytes. M protein of the immunoglobulin G (IgG) type was detected using immunoelectrophoresis. A bone marrow biopsy revealed infiltration of small mature lymphocytes, lymphoplasmacytoid cells with Dutcher bodies, grape cells, and Russell bodies. The MYD88 L265P mutation was detected in the abnormal peripheral lymphocytes, and a diagnosis of lymphoplasmacytoid lymphoma was established. MYD88 L265P mutation analysis is useful for making a diagnosis of non-IgM lymphoplasmacytoid lymphoma because it enables the differentiation from other low-grade B-cell malignancies.
一名76岁女性因白细胞增多和淋巴细胞异常前来我院就诊。采用免疫电泳检测到免疫球蛋白G（IgG）型M蛋白。骨髓活检显示有小成熟淋巴细胞、带有杜氏小体的淋巴浆细胞样细胞、葡萄状细胞和拉塞尔小体浸润。在异常外周淋巴细胞中检测到MYD88 L265P突变，确诊为淋巴浆细胞样淋巴瘤。MYD88 L265P突变分析有助于非IgM淋巴浆细胞样淋巴瘤的诊断，因为它能够与其他低级别B细胞恶性肿瘤相鉴别。
