一种研究金属诱导的 RAGE 相关病理学的新兴模型。
-An Emerging Model to Study Metal-Induced RAGE-Related Pathologies.
机构信息
Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Forchheimer Building, Room 209, Bronx, New York, NY 10461, USA.
出版信息
Int J Environ Res Public Health. 2018 Jul 4;15(7):1407. doi: 10.3390/ijerph15071407.
Abstract
The receptor for advanced glycation end products (RAGE), a multi-ligand receptor, is mostly associated with promoting inflammation and oxidative stress. In addition to advanced glycation end products (AGEs), its ligands include High mobility group box 1 protein (HMGB-1), S-100 proteins and beta-sheet fibrils. The effects of several metals and metalloids on RAGE expression and activation have been recently studied: in vivo and in vitro exposure to methylmercury, selenium, zinc, manganese, and arsenic was associated with a variety of RAGE-related alterations and behavioral impairments, which are mostly dependent upon the administration procedure (local vs. systemic) and age during exposure. Recently, has been proposed as a potential novel model for studying RAGE-related pathologies; preliminary data regarding such model and its potential contribution to the study of metal-induced RAGE-related pathologies are discussed.
摘要
晚期糖基化终产物受体（RAGE）是一种多配体受体，主要与促进炎症和氧化应激有关。除了晚期糖基化终产物（AGEs），其配体还包括高迁移率族蛋白 B1（HMGB-1）、S-100 蛋白和β-折叠纤维。最近研究了几种金属和类金属对 RAGE 表达和激活的影响：体内和体外暴露于甲基汞、硒、锌、锰和砷与多种 RAGE 相关的改变和行为障碍有关，这些改变和行为障碍主要取决于给药程序（局部与全身）和暴露期间的年龄。最近， 已被提议作为研究 RAGE 相关病理学的潜在新型模型；讨论了关于该模型及其对金属诱导的 RAGE 相关病理学研究的潜在贡献的初步数据。
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