Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile.
Department of Nutrition, Diabetes and Metabolism, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile; Department of Health Sciences-Nutrition and Dietetics, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
J Trace Elem Med Biol. 2018 Dec;50:560-565. doi: 10.1016/j.jtemb.2018.03.019. Epub 2018 Mar 26.
BACKGROUND/OBJECTIVE: Interest in healthy properties of food and nutrients as co-adjuvant in type-2 diabetes therapy has increased in recent years. Zinc supplementation trials have shown improvements in glycemic control in these patients, although it seems dependent on zinc status of the individuals. The objective of this study was to evaluate the relationship between zinc nutritional status and glucose homeostasis in patients with type-2 diabetes.
SUBJECTS/METHODS: Eighty patients with well controlled type-2 diabetes were recruited and clinical, anthropometric and dietary evaluations were performed. One week after, insulin sensitivity and beta cell function were assessed by a modified Frequently Sampled Intravenous Glucose Tolerance Test. Zinc status was assessed by plasma zinc and the size of rapidly Exchangeable Zinc Pool (EZP); zinc intake was also determined. Glucagon concentration was evaluated in a subsample of 36 patients.
Patients presented a normal zinc status although zinc intake was lower than recommended. Overall, no associations were observed between zinc status and glycemic control markers. Nevertheless, positive correlations were observed between EZP and fasting insulin concentration (ρ = 0.393, p = 0.021) and HOMA-IR (ρ = 0.386, p = 0.024) in women, and between plasma zinc concentration and HbA1c (ρ = 0.342, p = 0.020) in men.
No significant associations were found between zinc status and glycemic control parameters in patients with well-controlled type 2 diabetes and normal zinc status, although low-degree gender-dependent associations were observed. Further research is required to assess the role of zinc status in zinc deficient patients.
背景/目的：近年来，人们对食物和营养素有辅助治疗 2 型糖尿病的健康属性产生了浓厚的兴趣。锌补充试验表明，这些患者的血糖控制有所改善，但似乎依赖于个体的锌状态。本研究旨在评估 2 型糖尿病患者的锌营养状况与葡萄糖稳态之间的关系。
受试者/方法：招募了 80 名血糖控制良好的 2 型糖尿病患者，并进行了临床、人体测量和饮食评估。一周后，通过改良频繁采样静脉葡萄糖耐量试验评估胰岛素敏感性和β细胞功能。通过血浆锌和快速交换锌池（EZP）大小评估锌状态；还确定了锌的摄入量。在 36 名患者的亚样本中评估了胰高血糖素浓度。
患者的锌状态正常，尽管锌的摄入量低于推荐量。总体而言，锌状态与血糖控制标志物之间没有观察到关联。然而，在女性中，EZP 与空腹胰岛素浓度（ρ=0.393，p=0.021）和 HOMA-IR（ρ=0.386，p=0.024）呈正相关，在男性中，血浆锌浓度与 HbA1c 呈正相关（ρ=0.342，p=0.020）。
在血糖控制良好且锌状态正常的 2 型糖尿病患者中，锌状态与血糖控制参数之间未发现显著关联，但观察到低度性别依赖性关联。需要进一步研究来评估锌缺乏患者中锌状态的作用。
