1型糖尿病发病机制中的晚期糖基化终末产物受体（RAGE）
Receptor for Advanced Glycation End Products (RAGE) in Type 1 Diabetes Pathogenesis.
作者信息
Leung Sherman S, Forbes Josephine M, Borg Danielle J
机构信息
Glycation and Diabetes, Mater Research Institute, Translational Research Institute, The University of Queensland, 37 Kent St, Woolloongabba, Brisbane, Queensland, Australia.
School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland, Australia.
出版信息
Curr Diab Rep. 2016 Oct;16(10):100. doi: 10.1007/s11892-016-0782-y.
The receptor for advanced glycation end products (RAGE) is a novel protein increasingly studied in the pathogenesis of type 1 diabetes (T1D). RAGE is expressed by several immune cell types, including T cells, antigen-presenting cells, endothelial cells, and the endocrine cells of the pancreatic islets. RAGE binds various ligands including advanced glycation end products (AGEs), high-mobility group box protein 1 (HMGB1), S100 proteins, β-amyloid, β-sheet fibrils, and lipopolysaccharide. AGEs are a particularly interesting ligand because their exogenous introduction into the body can be accelerated by the consumption of AGE-rich processed foods. This review will detail RAGE isoforms and its ligands and discuss how RAGE binding on the aforementioned cells could be linked to T1D pathogenesis.
晚期糖基化终末产物受体（RAGE）是一种新型蛋白质，在1型糖尿病（T1D）发病机制中的研究日益增多。RAGE由多种免疫细胞类型表达，包括T细胞、抗原呈递细胞、内皮细胞和胰岛内分泌细胞。RAGE可结合多种配体，包括晚期糖基化终末产物（AGEs）、高迁移率族蛋白B1（HMGB1）、S100蛋白、β-淀粉样蛋白、β-折叠原纤维和脂多糖。AGEs是一种特别有趣的配体，因为食用富含AGEs的加工食品会加速其外源性进入体内。本综述将详细介绍RAGE异构体及其配体，并讨论上述细胞上的RAGE结合如何与T1D发病机制相关联。
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