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T cells in coeliac disease: a rational target for diagnosis and therapy.

作者信息

Hardy Melinda Y, Tye-Din Jason A

机构信息

Immunology Division, The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.

Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

出版信息

Nat Rev Gastroenterol Hepatol. 2018 Oct;15(10):583-584. doi: 10.1038/s41575-018-0043-4.

DOI:10.1038/s41575-018-0043-4
PMID:29973675
Abstract
摘要

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1
T cells in coeliac disease: a rational target for diagnosis and therapy.乳糜泻中的T细胞:诊断和治疗的合理靶点。
Nat Rev Gastroenterol Hepatol. 2018 Oct;15(10):583-584. doi: 10.1038/s41575-018-0043-4.
2
Reduction of tissue transglutaminase autoantibody levels by gluten-free diet is associated with changes in subsets of peripheral blood lymphocytes in children with newly diagnosed coeliac disease.无麸质饮食降低组织转谷氨酰胺酶自身抗体水平与新诊断的乳糜泻患儿外周血淋巴细胞亚群变化有关。
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A gut feeling for joint inflammation - using coeliac disease to understand rheumatoid arthritis.对关节炎症的直觉——利用乳糜泻来理解类风湿关节炎。
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Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease.与乳糜泻患儿调节性T细胞(Treg)上CD101(+) /CD129(+)高表达形成对比的是,1型糖尿病患儿Treg细胞上CD39(+) /CD45RA(+)表达较低。
Clin Exp Immunol. 2015 Apr;180(1):70-82. doi: 10.1111/cei.12559.
5
Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia.麸质在体外对乳糜泻黏膜的刺激可诱导固有层CD4+ T细胞和巨噬细胞的激活(CD25),但不会导致隐窝细胞增生。
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Keratinocyte growth factor and coeliac disease.角质形成细胞生长因子与乳糜泻
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[Interactions between enterocytes and lymphocytes in the pathogenesis of celiac disease].[乳糜泻发病机制中肠上皮细胞与淋巴细胞之间的相互作用]
Z Gesamte Inn Med. 1991 Jul;46(9):306-9.
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Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ alpha/beta cells in the lamina propria but proliferation (Ki-67) of alpha/beta and gamma/delta cells in the epithelium.腹腔病变中的活化T淋巴细胞:固有层中CD4⁺α/β细胞的非增殖性活化(CD25),但上皮中α/β和γ/δ细胞的增殖(Ki-67)。
Eur J Immunol. 1993 Feb;23(2):505-10. doi: 10.1002/eji.1830230231.
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Increase in T-cell subsets of oral mucosa: a late immune response in patients with treated coeliac disease?口腔黏膜T细胞亚群增加:乳糜泻患者治疗后的晚期免疫反应?
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Dietary modifications: food dependent autoimmunity in coeliac disease.饮食调整:乳糜泻中的食物依赖性自身免疫
Gut. 1998 Nov;43(5):599-600. doi: 10.1136/gut.43.5.599.

引用本文的文献

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Whole blood interleukin-2 release test to detect and characterize rare circulating gluten-specific T cell responses in coeliac disease.检测和分析乳糜泻患者罕见循环中麸质特异性 T 细胞应答的全血白细胞介素-2 释放试验。
Clin Exp Immunol. 2021 Jun;204(3):321-334. doi: 10.1111/cei.13578. Epub 2021 Feb 28.
2
Mediterranean Gluten-Free Diet: Is It a Fair Bet for the Treatment of Gluten-Related Disorders?地中海无麸质饮食:它是治疗麸质相关疾病的明智选择吗?
Front Nutr. 2020 Dec 2;7:583981. doi: 10.3389/fnut.2020.583981. eCollection 2020.
3
Iron Absorption in Celiac Disease and Nutraceutical Effect of 7-Hydroxymatairesinol. Mini-Review.
乳糜泻中的铁吸收和 7-羟基马替瑞林的营养功效。小型综述。
Molecules. 2020 Apr 27;25(9):2041. doi: 10.3390/molecules25092041.
4
CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease.在乳糜泻中,麦胶特异性 T 细胞上的 CD38 表达是 gluten 再暴露的强有力标志物。
United European Gastroenterol J. 2019 Dec;7(10):1337-1344. doi: 10.1177/2050640619874183. Epub 2019 Sep 7.