Huang Hua, Li Yapeng, Liang Jinyi, Finkelman Fred D
The Department of Biomedical Research, National Jewish Health, Denver, CO, United States.
The Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, IL, United States.
Front Immunol. 2018 Jun 20;9:1392. doi: 10.3389/fimmu.2018.01392. eCollection 2018.
Histamine is a critical mediator of IgE/mast cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of gene expression in mammals is still poorly understood. In this review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis.
组胺是IgE/肥大细胞介导的过敏反应的关键介质、一种神经递质以及胃酸分泌的调节剂。组胺是一种单胺，由氨基酸组氨酸通过组氨酸脱羧酶（HDC）催化的反应合成，该酶从组氨酸中去除羧基。尽管组胺很重要，但哺乳动物中组胺基因表达的转录调控仍知之甚少。在这篇综述中，我们重点讨论哺乳动物组胺合成分子调控方面的研究进展。
