Volonté Cinzia, Liguori Francesco, Amadio Susanna
National Research Council, Institute for Systems Analysis and Computer Science "A. Ruberti", Via Dei Taurini 19, 00185 Rome, Italy.
Experimental Neuroscience and Neurological Disease Models, Santa Lucia Foundation IRCCS, Via Del Fosso di Fiorano 65, 00143 Rome, Italy.
Int J Mol Sci. 2024 Apr 18;25(8):4449. doi: 10.3390/ijms25084449.
The present work intends to provide a closer look at histamine in . This choice is motivated firstly because has proven over the years to be a very simple, but powerful, model organism abundantly assisting scientists in explaining not only normal functions, but also derangements that occur in higher organisms, not excluding humans. Secondly, because histamine has been demonstrated to be a pleiotropic master molecule in pharmacology and immunology, with increasingly recognized roles also in the nervous system. Indeed, it interacts with various neurotransmitters and controls functions such as learning, memory, circadian rhythm, satiety, energy balance, nociception, and motor circuits, not excluding several pathological conditions. In view of this, our review is focused on the knowledge that the use of has added to the already vast histaminergic field. In particular, we have described histamine's actions on photoreceptors sustaining the visual system and synchronizing circadian rhythms, but also on temperature preference, courtship behavior, and mechanosensory transmission. In addition, we have highlighted the pathophysiological consequences of mutations on genes involved in histamine metabolism and signaling. By promoting critical discussion and further research, our aim is to emphasize and renew the importance of histaminergic research in biomedicine through the exploitation of , hopefully extending the scientific debate to the academic, industry, and general public audiences.
本研究旨在更深入地探讨[具体生物]中的组胺。做出这一选择的首要动机是，多年来[具体生物]已被证明是一种非常简单但功能强大的模式生物，它不仅能极大地帮助科学家解释正常功能，还能解释高等生物（包括人类）中出现的紊乱情况。其次，因为组胺在药理学和免疫学中已被证明是一种多效性的主控分子，在神经系统中的作用也日益得到认可。事实上，它与多种神经递质相互作用，并控制诸如学习、记忆、昼夜节律、饱腹感、能量平衡、痛觉感受和运动回路等功能，还涉及多种病理状况。鉴于此，我们的综述聚焦于利用[具体生物]在已经非常庞大的组胺能领域所增加的知识。特别是，我们描述了组胺对维持视觉系统和同步昼夜节律的光感受器的作用，以及对温度偏好、求偶行为和机械感觉传递的作用。此外，我们强调了组胺代谢和信号传导相关基因突变的病理生理后果。通过促进批判性讨论和进一步研究，我们的目标是通过利用[具体生物]来强调和重申组胺能研究在生物医学中的重要性，希望将科学辩论扩展到学术界、产业界和普通公众。
