α-肾上腺素能受体阻断对特发性、生理性及异丙肾上腺素诱发震颤的不同作用：特发性震颤中枢起源的证据
Differential effects of alpha-adrenoceptor blockade on essential, physiological and isoprenaline-induced tremor: evidence for a central origin of essential tremor.
作者信息
Abila B, Wilson J F, Marshall R W, Richens A
出版信息
J Neurol Neurosurg Psychiatry. 1985 Oct;48(10):1031-6. doi: 10.1136/jnnp.48.10.1031.
Abstract
Intravenous thymoxamine reduced the power of essential tremor but increased that of physiological and isoprenaline-induced tremor. These findings indicate that essential and physiological tremor have dissimilar pathophysiological mechanisms. They also suggest that central adrenergic mechanisms are involved in the pathophysiology of essential tremor and that isoprenaline-induced tremor is not a good model of essential tremor. Furthermore, alpha-adrenoceptor blockers may be a useful therapy for essential tremor.
摘要
静脉注射胸腺嘧啶可降低特发性震颤的强度，但会增加生理性震颤和异丙肾上腺素诱发震颤的强度。这些发现表明，特发性震颤和生理性震颤具有不同的病理生理机制。它们还提示，中枢肾上腺素能机制参与了特发性震颤的病理生理过程，且异丙肾上腺素诱发的震颤并非特发性震颤的良好模型。此外，α-肾上腺素能受体阻滞剂可能是治疗特发性震颤的一种有效疗法。
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