School of Communication Sciences and Disorders, University of Western Ontario, London, Canada.
Graduate Program in Health & Rehabilitation Sciences, University of Western Ontario, London, Canada.
J Speech Lang Hear Res. 2018 Jul 13;61(7):1718-1730. doi: 10.1044/2018_JSLHR-L-17-0420.
Immature auditory processing has been proposed to underlie language impairments in children with developmental language disorder (DLD; also known as specific language impairment). Using newly available normative auditory evoked potential (AEP) waveforms, we estimated AEP maturity in individual children with DLD and explored whether this maturational index was related to their language abilities.
AEPs were elicited by 225 trials of a 490-Hz pure tone. Using intraclass correlation and our previously established normative AEP waveforms of 7- to 10-year-old children with typical development, we estimated the age equivalent of the AEPs (AEP-age) from 21 children with DLD. The relation between AEP maturity and language was explored through regression analysis.
AEP-age predicted 31% of the variance in the language abilities of children with DLD. The AEP-age of children with mild DLD was similar to their chronological age, whereas children with moderate-severe DLD showed, on average, a 1.3-year delay in their neural responses. AEP-age predicted receptive, but not expressive, language performance.
Maturation in auditory neural responses is a significant predictor of language ability, particularly in children with moderate-severe DLD.
发育性语言障碍（DLD；也称为特定语言障碍）儿童的语言障碍可能源于不成熟的听觉处理。我们利用新获得的正常听觉诱发电位（AEP）波形，估计了 DLD 儿童的 AEP 成熟度，并探讨了这种成熟指数是否与其语言能力相关。
通过 225 次 490Hz 纯音试验引出 AEP。使用内部一致性和我们之前建立的 7-10 岁正常发育儿童的正常 AEP 波形，我们从 21 名 DLD 儿童中估计了 AEP 的年龄当量（AEP-age）。通过回归分析探讨了 AEP 成熟度与语言之间的关系。
AEP-age 可预测 DLD 儿童语言能力的 31%。轻度 DLD 儿童的 AEP-age 与他们的实际年龄相似，而中重度 DLD 儿童的神经反应平均延迟了 1.3 年。AEP-age 预测了接受性语言，但不能预测表达性语言表现。
听觉神经反应的成熟度是语言能力的一个重要预测指标，特别是在中重度 DLD 儿童中。
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