伴有和不伴有发育性语言障碍（DLD）个体的背侧和腹侧语言通路中的大脑结构改变。
Altered brain structures in the dorsal and ventral language pathways in individuals with and without developmental language disorder (DLD).
机构信息
Department of Communication Sciences and Disorders, University of Iowa, Iowa City, IA, 52242, USA.
Department of Psychology, Florida International University, Miami, FL, USA.
出版信息
Brain Imaging Behav. 2020 Dec;14(6):2569-2586. doi: 10.1007/s11682-019-00209-1.
Abstract
Developmental Language Disorder (DLD) is a neurodevelopmental disorder characterized by difficulty learning and using language, and this difficulty cannot be attributed to other developmental conditions. The aim of the current study was to examine structural differences in dorsal and ventral language pathways between adolescents and young adults with and without DLD (age range: 14-27 years) using anatomical magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Results showed age-related structural brain differences in both dorsal and ventral pathways in individuals with DLD. These findings provide evidence for neuroanatomical correlates of persistent language deficits in adolescents/young adults with DLD, and further suggest that this brain-language relationship in DLD is better characterized by taking account the dynamic course of the disorder along development.
摘要
发展性语言障碍（DLD）是一种神经发育障碍，其特征是学习和使用语言有困难，且这种困难不能归因于其他发育状况。本研究的目的是使用解剖磁共振成像（MRI）和扩散张量成像（DTI）来检查有和没有 DLD 的青少年和年轻成人（年龄范围：14-27 岁）之间的背侧和腹侧语言通路的结构差异。结果表明，DLD 个体的背侧和腹侧通路均存在与年龄相关的结构脑差异。这些发现为青少年/年轻成人 DLD 持续语言缺陷的神经解剖学相关性提供了证据，并进一步表明，考虑到该疾病在发育过程中的动态病程，DLD 中的这种大脑-语言关系能够得到更好的描述。
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本文引用的文献
1
Dorsal language stream anomalies in an inherited speech disorder.
Brain. 2019 Apr 1;142(4):966-977. doi: 10.1093/brain/awz018.
2
Altered gray matter volumes in language-associated regions in children with developmental language disorder and speech sound disorder.
Dev Psychobiol. 2018 Nov;60(7):814-824. doi: 10.1002/dev.21762. Epub 2018 Aug 13.
3
Immature Auditory Evoked Potentials in Children With Moderate-Severe Developmental Language Disorder.
J Speech Lang Hear Res. 2018 Jul 13;61(7):1718-1730. doi: 10.1044/2018_JSLHR-L-17-0420.
4
The mis-wired language network in children with developmental language disorder: insights from DTI tractography.
Brain Imaging Behav. 2019 Aug;13(4):973-984. doi: 10.1007/s11682-018-9903-3.
5
A Brain Marker for Developmental Speech Disorders.
J Pediatr. 2018 Jul;198:234-239.e1. doi: 10.1016/j.jpeds.2018.02.043. Epub 2018 Apr 25.
6
Broca and Wernicke are dead, or moving past the classic model of language neurobiology.
Brain Lang. 2016 Nov;162:60-71. doi: 10.1016/j.bandl.2016.08.004. Epub 2016 Aug 30.
7
Neurobiological Basis of Language Learning Difficulties.
Trends Cogn Sci. 2016 Sep;20(9):701-714. doi: 10.1016/j.tics.2016.06.012. Epub 2016 Jul 13.
8
The impact of nonverbal ability on prevalence and clinical presentation of language disorder: evidence from a population study.
J Child Psychol Psychiatry. 2016 Nov;57(11):1247-1257. doi: 10.1111/jcpp.12573. Epub 2016 May 16.
9
Experience-Dependent Brain Development as a Key to Understanding the Language System.
Top Cogn Sci. 2016 Apr;8(2):446-58. doi: 10.1111/tops.12194. Epub 2016 Mar 3.
10
Structural alterations of the language connectome in children with specific language impairment.
Brain Lang. 2015 Dec;151:35-41. doi: 10.1016/j.bandl.2015.10.003. Epub 2015 Nov 21.
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