Wegener Tankred, Gündling Peter W, Holubarsch Christian J F, Mayer Johannes Gottfried, Schini-Kerth Valerie B, Schmidt-Trucksäss Arno, Stange Rainer
, Brückstraße 11, D-69469, Weinheim, Deutschland.
Hochschule Fresenius Idstein, Johann-Wolfgang-Goethe-Universität Frankfurt am Main, Frankfurt am Main, Deutschland.
MMW Fortschr Med. 2018 Jul;160(Suppl 4):1-7. doi: 10.1007/s15006-018-0725-4. Epub 2018 Jul 4.
Traditionally, hawthorn extract has been used for preventive and curative support in mild forms of age-related cardiovascular problems. There are now solid data demonstrating pre-clinical effects and mechanisms of action on a molecular-biological and cellular level that appear to be of particular interest in influencing vascular ageing and in arterial vascular disorders.
The review presents the results of a meeting of experts that took place to work out a current assessment of the therapeutic suitability of hawthorn extract in the treatment of cardiovascular disease.
Although currently no general recommendation can be given on the use of hawthorn extract in cardiac insufficiency, its use is indicated for typical challenges arising in general practice, where particularly patients with functional cardiorespiratory complaints present, possibly those with cardiac insufficiency with preserved heart function for whom there has thus far been no effective therapy apart from exercise. This recommendation is supported by the findings of studies on the safety and very good tolerability of hawthorn extract, particularly for therapy adjuvant to standard practice.
传统上，山楂提取物一直用于轻度年龄相关性心血管问题的预防和治疗支持。现在有确凿的数据表明，其在分子生物学和细胞水平上的临床前效应和作用机制似乎对影响血管衰老和动脉血管疾病特别有意义。
本综述展示了一次专家会议的结果，该会议旨在对山楂提取物治疗心血管疾病的治疗适用性进行当前评估。
尽管目前无法就山楂提取物在心脏功能不全中的使用给出一般性建议，但在全科医疗中出现的典型问题中，其使用是有指征的，特别是那些有功能性心肺症状的患者，可能是心脏功能保留的心脏功能不全患者，迄今为止除了运动外尚无有效治疗方法。这一建议得到了关于山楂提取物安全性和良好耐受性研究结果的支持，特别是作为标准治疗的辅助治疗。
