Bazelle J, Threlfall A, Whitley N
Davies Veterinary Specialists, Hitchin, SG5 3HR, UK.
J Small Anim Pract. 2018 Jul 4. doi: 10.1111/jsap.12867.
Diverse drugs with presumed cytoprotective effect have been used therapeutically in small animal veterinary practice for various gastro-intestinal conditions such as oesophagitis, gastric ulceration, gastritis or chronic gastro-enteropathies. Their efficacy has been doubted in human medicine, raising similar questions in the veterinary field. The aim of this review was to assess the current evidence on the efficacy and safety of these drugs in dogs and cats. Through a systematic review of the literature, we identified 37 articles on the use of misoprostol, sucralfate and other gastroprotectants in dogs and cats. There was evidence to support use of misoprostol in the prevention of aspirin-induced gastroduodenal mucosal injury in dogs, and for use of sucralfate in the prevention of acid-induced oesophagitis in cats. However, the overall quality of evidence supporting the use of these drugs in small animal patients was poor. In contrast, there was evidence of important adverse effects, especially drug interaction and gastro-intestinal signs. We therefore recommend prescribing these drugs with caution until further well-conducted studies reveal a useful gastroprotectant effect.
多种具有假定细胞保护作用的药物已在小动物兽医实践中用于治疗各种胃肠道疾病，如食管炎、胃溃疡、胃炎或慢性胃肠病。它们在人类医学中的疗效受到质疑，这在兽医领域也引发了类似问题。本综述的目的是评估这些药物在犬猫中的疗效和安全性的现有证据。通过对文献的系统综述，我们确定了37篇关于米索前列醇、硫糖铝和其他胃保护剂在犬猫中使用的文章。有证据支持米索前列醇用于预防犬阿司匹林诱导的胃十二指肠粘膜损伤，以及硫糖铝用于预防猫酸诱导的食管炎。然而，支持这些药物在小动物患者中使用的证据总体质量较差。相比之下，有证据表明存在重要的不良反应，尤其是药物相互作用和胃肠道症状。因此，我们建议谨慎开这些药物，直到进一步的高质量研究揭示出有用的胃保护作用。
