DVM, PhD, DACVIM-SAIM, SA nutrition* Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
DVM College of Veterinary Medicine, NC State University, Raleigh, NC, USA.
J Feline Med Surg. 2024 Aug;26(8):1098612X241274235. doi: 10.1177/1098612X241274235.
Acid-related disorders including esophagitis and gastroduodenal ulceration are uncommon in the cat. However, when they occur, they can have devastating consequences and require targeted intervention, including the use of gastroprotectants. Careful consideration of the causes of esophagitis and gastroduodenal ulceration can help the clinician to determine which gastroprotectant to use, and when to begin and end gastroprotective therapy.
Gastroprotectants remain one of the most misused classes of drugs in veterinary and human medicine. There are very few studies evaluating the efficacy of gastroprotective agents in cats. Furthermore, goals for the degree of gastric acid suppression are extrapolated from studies performed in dogs and humans.
This review provides a foundation for the logical approach to the choice of gastroprotectant as indicated by the disease process, and is aimed at all veterinarians who prescribe gastroprotectants for use in cats.
The guidance provided in this review is supported by current literature, including consensus opinion from the American College of Veterinary Internal Medicine. Gaps in evidence for use of gastroprotectants in cats are filled by extrapolations from studies performed in dogs and humans.
包括食管炎和胃十二指肠溃疡在内的酸相关疾病在猫中并不常见。然而，当它们发生时，可能会产生破坏性的后果，需要有针对性的干预，包括使用胃保护剂。仔细考虑食管炎和胃十二指肠溃疡的原因可以帮助临床医生确定使用哪种胃保护剂，以及何时开始和结束胃保护治疗。
胃保护剂仍然是兽医和人类医学中最滥用的药物之一。很少有研究评估胃保护剂在猫中的疗效。此外，胃酸抑制程度的目标是从在狗和人中进行的研究中推断出来的。
本综述为根据疾病过程选择胃保护剂提供了一个合理的方法，旨在为所有为猫开具胃保护剂的兽医提供帮助。
本综述提供的指导依据是当前的文献，包括美国兽医内科医师学院的共识意见。通过从狗和人中进行的研究推断，填补了胃保护剂在猫中使用的证据空白。
