Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Curr Mol Med. 2018;18(2):91-99. doi: 10.2174/1566524018666180705110412.
Leptin and insulin resistance have been pointed out to play a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Increasing genes were shown to be associated with the risk of NAFLD.
The study aimed to investigate the genetic association between two leptin receptor (LEPR) polymorphisms (Q223R and K109R) and the NAFLD risk.
Studies were retrieved and included by using PubMed, Web of Science, the Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI) and EMBASE database. Genetic associations were assessed with pooled odds ratios (ORs) with 95% confidence intervals (CIs).
Five case-control studies with 1711 NAFLD patients and 1732 healthy controls were included in this meta-analysis. The K109R was significantly associated with NAFLD in allelic model in Southeast Asian subgroup (p=0.01, OR=0.59, 95% CI [0.39- 0.90]), but not in Chinese subgroup (p=0.24, OR=1.10, 95% CI [0.94-1.29]). The Q223R was significantly associated with NAFLD in both allelic and recessive models (allelic model: p<0.001, OR=0.57, 95% CI [0.50-0.65]; recessive model: p=0.001, OR=0.67, 95% CI [0.52-0.85]). However, subgroup analysis showed that the significant association between Q223R and NAFLD in allelic model cannot be found in Southeast Asians subgroup (p=0.07, OR=0.67, 95% CI [0.52-0.85]).
LEPR K109R might be a susceptible factor for NAFLD in Southeast Asian population. And LEPR Q223R might be a susceptible factor for NAFLD in Chinese population.
瘦素和胰岛素抵抗被指出在非酒精性脂肪性肝病（NAFLD）的发病机制中起作用。越来越多的基因与 NAFLD 的风险相关。
本研究旨在探讨两种瘦素受体（LEPR）多态性（Q223R 和 K109R）与 NAFLD 风险的遗传关联。
通过使用 PubMed、Web of Science、Cochrane 图书馆数据库、中国知网（CNKI）和 EMBASE 数据库检索并纳入研究。使用合并优势比（OR）及其 95%置信区间（CI）评估遗传关联。
本荟萃分析纳入了 5 项病例对照研究，共纳入 1711 例 NAFLD 患者和 1732 例健康对照。K109R 在东南亚亚组的等位基因模型中与 NAFLD 显著相关（p=0.01，OR=0.59，95%CI [0.39-0.90]），但在中国亚组中无显著相关性（p=0.24，OR=1.10，95%CI [0.94-1.29]）。Q223R 在等位基因和隐性模型中均与 NAFLD 显著相关（等位基因模型：p<0.001，OR=0.57，95%CI [0.50-0.65]；隐性模型：p=0.001，OR=0.67，95%CI [0.52-0.85]）。然而，亚组分析显示，Q223R 与东南亚人群中 NAFLD 的等位基因模型之间的显著关联无法找到（p=0.07，OR=0.67，95%CI [0.52-0.85]）。
LEPR K109R 可能是东南亚人群中 NAFLD 的易感因素。而 LEPR Q223R 可能是中国人群中 NAFLD 的易感因素。
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