细胞骨架交响曲：归功于 TOG。

A Cytoskeletal Symphony: Owed to TOG.

机构信息

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

出版信息

Dev Cell. 2018 Jul 2;46(1):5-7. doi: 10.1016/j.devcel.2018.06.010.

DOI:10.1016/j.devcel.2018.06.010

Abstract

Like permutating motifs in music, similar protein folds are employed across biology for distinct functions. In this issue of Developmental Cell, Aher et al. (2018) provide insight into how variable TOG domains within an array in the microtubule regulator CLASP are used to prevent microtubule catastrophe and potentiate rescue.

摘要

就像音乐中不断变化的主题一样，相似的蛋白质折叠在生物学中被用于不同的功能。在本期《发育细胞》中，Aher 等人（2018）提供了深入的见解，说明了微管调节蛋白 CLASP 中阵列内的可变 TOG 结构域如何被用来防止微管崩溃并增强救援。