Boström Kristina I, Yao Jiayi, Wu Xiuju, Yao Yucheng
Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, U.S.A.
The Molecular Biology Institute at UCLA, Los Angeles, CA 90095-1570, U.S.A.
J Cell Biol Histol. 2018 Jun;1(1). Epub 2018 Jun 8.
Endothelial heterogeneity reflects many functions performed by endothelial cells (ECs) in various tissues. However, the origin of this heterogeneity is unclear. Here, we report that tissue-specific ECs in lungs, brain and liver co-expressed the lineage markers of their coordinating tissue-specific cells at very early stages. Specifically, we found that the pulmonary EC population was significantly suppressed after pulmonary epithelial-specific ( mediated) deletion of fetal liver kinase-1 (Flk1). Together, the results suggest that tissues-specific ECs may originate from the same progenitor cells as tissue-specific cells.
内皮细胞异质性反映了内皮细胞（ECs）在各种组织中执行的多种功能。然而，这种异质性的起源尚不清楚。在这里，我们报告肺、脑和肝脏中的组织特异性内皮细胞在非常早期阶段共同表达了其协调组织特异性细胞的谱系标记。具体而言，我们发现肺上皮特异性（介导）缺失胎儿肝激酶-1（Flk1）后，肺内皮细胞群体受到显著抑制。综合来看，这些结果表明组织特异性内皮细胞可能与组织特异性细胞起源于相同的祖细胞。
