Yao Yucheng, Yao Jiayi, Boström Kristina I
Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Molecular Biology Institute, UCLA, Los Angeles, CA, United States.
Front Cardiovasc Med. 2019 Mar 28;6:30. doi: 10.3389/fcvm.2019.00030. eCollection 2019.
The SRY (Sex Determining Region Y)-related HMG box of DNA binding proteins, referred to as SOX transcription factors, were first identified as critical regulators of male sex determination but are now known to play an important role in vascular development and disease. SOX7, 17, and 18 are essential in endothelial differentiation and SOX2 has emerged as an essential mediator of endothelial-mesenchymal transitions (EndMTs), a mechanism that enables the endothelium to contribute cells with abnormal cell differentiation to vascular disease such as calcific vasculopathy. In the following paper, we review published information on the SOX transcription factors in endothelial differentiation and hypothesize that SOX2 acts as a mediator of EndMTs that contribute to vascular calcification.
与DNA结合蛋白的SRY（性别决定区域Y）相关的HMG盒，被称为SOX转录因子，最初被鉴定为男性性别决定的关键调节因子，但现在已知其在血管发育和疾病中发挥重要作用。SOX7、17和18在内皮分化中至关重要，而SOX2已成为内皮-间充质转化（EndMTs）的关键介质，这是一种使内皮细胞能够将细胞分化异常的细胞贡献给血管疾病（如钙化性血管病）的机制。在接下来的论文中，我们回顾了已发表的关于SOX转录因子在内皮分化中的信息，并假设SOX2作为EndMTs的介质，促成血管钙化。
