Yoshikawa K, Maruyama K
Jpn J Clin Oncol. 1985 Sep;15(3):499-503.
A total of 2,608 patients with gastric cancer received curative or palliative resection in the surgical department of the National Cancer Center Hospital during the 13-year period from 1968 to 1980. Of these, 261 patients with gastric cancer invading to the proper muscle layer (pm cancer) were studied. The incidence of pm cancer was 10.0% (261/2,608). Annual incidence showed a tendency of a little increase as compared with the pronounced increase in early cancer in recent years. Male patients comprised 67% of the total. Sixty- to 69-yr-old patients constituted 28.7%. This cancer occurred more frequently in the lower portion and the lesser curvature of the stomach. The type looking like early cancer comprised 38.3% (100/261). Histologically, undifferentiated types constituted 50% (131/261) and differentiated types comprised 44% (117/261). There were nine patients with distant metastasis despite the fact that the invasion was limited to the pm layer. Eighty-one (31%) of the 261 patients had died by November 1984. However, the survival period was longer than that for advanced cancer invading to the serosal layer. Concerning the cause of death, 48 (59.2%) of the 81 patients died of recurrent cancer and 27 (33.3%) died of nonmalignant disease. Death caused by hematogenous metastasis, especially liver metastasis, was the most characteristic. A close relationship was not found between the mode of invasion to the pm layer and mortality.
1968年至1980年的13年间，共有2608例胃癌患者在国立癌症中心医院外科接受了根治性或姑息性切除手术。其中，对261例侵犯固有肌层的胃癌患者（pm癌）进行了研究。pm癌的发病率为10.0%（261/2608）。与近年来早期癌发病率的显著上升相比，pm癌的年发病率呈略有上升的趋势。男性患者占总数的67%。60至69岁的患者占28.7%。这种癌症在胃的下部和小弯处更为常见。类似早期癌的类型占38.3%（100/261）。组织学上，未分化型占50%（131/261），分化型占44%（117/261）。尽管侵犯仅限于pm层，但仍有9例发生远处转移。到1984年11月，261例患者中有81例（31%）死亡。然而，其生存期比侵犯浆膜层的进展期癌症更长。关于死亡原因，81例患者中有48例（59.2%）死于复发性癌症，27例（33.3%）死于非恶性疾病。血行转移尤其是肝转移导致的死亡最为典型。未发现侵犯pm层的方式与死亡率之间存在密切关系。
