胃癌：分类、组织病理学和分子病理学的应用。
Gastric cancer: Classification, histology and application of molecular pathology.
出版信息
J Gastrointest Oncol. 2012 Sep;3(3):251-61. doi: 10.3978/j.issn.2078-6891.2012.021.
Abstract
Gastric cancer remains one of the deadly diseases with poor prognosis. New classification of gastric cancers based on histologic features, genotypes and molecular phenotypes helps better understand the characteristics of each subtype, and improve early diagnosis, prevention and treatment. The objective of this article is to review the new classification of gastric cancers and the up-to-date guidance in the application of molecular testing.
摘要
胃癌仍然是预后不良的致命疾病之一。基于组织学特征、基因型和分子表型的新胃癌分类有助于更好地了解每种亚型的特征，并改善早期诊断、预防和治疗。本文的目的是综述胃癌的新分类以及分子检测应用的最新指南。
相似文献
1
Gastric cancer: Classification, histology and application of molecular pathology.胃癌：分类、组织病理学和分子病理学的应用。
J Gastrointest Oncol. 2012 Sep;3(3):251-61. doi: 10.3978/j.issn.2078-6891.2012.021.
2
Canine Gastric Pathology: A Review.犬胃病理学综述
J Comp Pathol. 2016 Jan;154(1):9-37. doi: 10.1016/j.jcpa.2015.10.181. Epub 2016 Jan 13.
3
Receptor tyrosine kinase amplified gastric cancer: Clinicopathologic characteristics and proposed screening algorithm.受体酪氨酸激酶扩增型胃癌：临床病理特征及建议的筛查算法
Oncotarget. 2016 Nov 1;7(44):72099-72112. doi: 10.18632/oncotarget.12291.
4
CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis And Treatment.CDH1基因与遗传性弥漫性胃癌综合征：分子与组织学改变及其对诊断和治疗的意义
Front Pharmacol. 2018 Dec 5;9:1421. doi: 10.3389/fphar.2018.01421. eCollection 2018.
5
20-Year Comparative Survival and Mortality of Cancer of the Stomach by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period, Disease Duration & Selected ICD-O-3 Oncologic Phenotypes: .按年龄、性别、种族、分期、分级、队列入组时间、疾病持续时间及选定的ICD-O-3肿瘤学表型对胃癌进行的20年生存和死亡率比较：
J Insur Med. 2019;48(1):5-23. doi: 10.17849/insm-48-1-1-19.1. Epub 2019 Oct 14.
6
Clinicopathological features and outcomes in patients undergoing radical resection for early gastric cancer with signet ring cell histology.早期胃癌印戒细胞组织学类型患者行根治性切除术后的临床病理特征及预后
J Visc Surg. 2015 Dec;152(6):357-61. doi: 10.1016/j.jviscsurg.2015.09.021. Epub 2015 Oct 23.
7
Gastric cancer: new genetic developments.胃癌：新的遗传学进展
J Surg Oncol. 2005 Jun 1;90(3):114-33; discussion 133. doi: 10.1002/jso.20214.
8
Clinical features and cancer risk in families with pathogenic variants irrespective of clinical criteria.无论是否符合临床标准，具有致病性变异的家族的临床特征和癌症风险。
J Med Genet. 2019 Dec;56(12):838-843. doi: 10.1136/jmedgenet-2019-105991. Epub 2019 Jul 11.
9
A cohort study and meta-analysis between histopathological classification and prognosis of gastric carcinoma.一项关于胃癌组织病理学分类与预后的队列研究和荟萃分析。
Anticancer Agents Med Chem. 2013 Feb;13(2):227-34. doi: 10.2174/1871520611313020007.
10
THE STUDY OF THE EXPRESSION OF CDH1, KI67, P53 AND HER2 IN DIFFUSE GASTRIC CARCINOMA.CDH1、KI67、P53和HER2在弥漫性胃癌中的表达研究
Georgian Med News. 2020 Feb(299):147-150.
引用本文的文献
1
Comprehensive genetic analysis of poorly differentiated gastric cancer in young females.年轻女性低分化胃癌的综合基因分析
Ann Gastroenterol Surg. 2025 Apr 29;9(5):926-932. doi: 10.1002/ags3.70020. eCollection 2025 Sep.
2
One-carbon metabolic pathway is a novel molecular signature for CD44-positive intestinal-type gastric cancer.一碳代谢途径是CD44阳性肠型胃癌的一种新型分子标志物。
Cell Death Discov. 2025 Aug 23;11(1):399. doi: 10.1038/s41420-025-02704-5.
3
OncoMet: a deep learning framework for the prediction of oncogenic signaling pathways and metastasis in esophageal cancer patients using histopathology images from primary tumors.OncoMet：一种深度学习框架，用于利用原发性肿瘤的组织病理学图像预测食管癌患者的致癌信号通路和转移情况。
J Transl Med. 2025 Aug 21;23(1):945. doi: 10.1186/s12967-025-06914-4.
4
Galectins as Master Regulators of Gastric Cancer Progression.半乳糖凝集素作为胃癌进展的主要调节因子
Cells. 2025 Jul 16;14(14):1090. doi: 10.3390/cells14141090.
5
Circ-malat1 promotes gastric cell growth via miR-154-5p/CCND2.环状- MALAT1通过miR - 154 - 5p/CCND2促进胃细胞生长。
Front Genet. 2025 Jul 10;16:1594354. doi: 10.3389/fgene.2025.1594354. eCollection 2025.
6
Prognostic Value of Inflammatory Indices in Papillary Gastric Carcinoma with Different Proportions of Papillary Components.不同乳头成分比例的胃乳头状癌中炎症指标的预后价值
J Inflamm Res. 2025 Jul 15;18:9243-9259. doi: 10.2147/JIR.S532396. eCollection 2025.
7
A Histopathological and Surgical Analysis of Gastric Cancer: A Two-Year Experience in a Single Center.胃癌的组织病理学与手术分析：单中心两年经验
Cancers (Basel). 2025 Jul 2;17(13):2219. doi: 10.3390/cancers17132219.
8
Gastric Medullary Carcinoma.胃髓样癌
Radiol Imaging Cancer. 2025 Jul;7(4):e250189. doi: 10.1148/rycan.250189.
9
Endoscopic Submucosal Dissection in the Treatment of Patients With Papillary Early Gastric Cancer.内镜下黏膜下剥离术治疗乳头型早期胃癌患者
Korean J Helicobacter Up Gastrointest Res. 2025 Mar;25(1):78-80. doi: 10.7704/kjhugr.2024.0065. Epub 2025 Mar 7.
10
Circulating exosomal miR-17-92 cluster serves as a novel noninvasive diagnostic marker for patients with gastric cancer.循环外泌体miR-17-92簇作为胃癌患者一种新型的非侵入性诊断标志物。
World J Gastrointest Oncol. 2025 May 15;17(5):104776. doi: 10.4251/wjgo.v17.i5.104776.
本文引用的文献
1
HER2 testing in gastric cancer: a practical approach.胃肿瘤 HER2 检测：实用方法。
Mod Pathol. 2012 May;25(5):637-50. doi: 10.1038/modpathol.2011.198. Epub 2012 Jan 6.
2
Gastric carcinoma with invasive micropapillary pattern and its association with lymph node metastasis.胃浸润性微乳头状癌及其与淋巴结转移的关系。
Histopathology. 2011 Dec;59(6):1081-9. doi: 10.1111/j.1365-2559.2011.04055.x.
3
Dihydropyrimidine dehydrogenase gene as a major predictor of severe 5-fluorouracil toxicity.二氢嘧啶脱氢酶基因是预测氟尿嘧啶严重毒性的主要指标。
Pharmacogenomics. 2011 Sep;12(9):1321-36. doi: 10.2217/pgs.11.72.
4
Translational medicine and reliability of single-nucleotide polymorphism studies: can we believe in SNP reports or not?转化医学与单核苷酸多态性研究的可靠性：我们能否相信 SNP 报告？
Int J Med Sci. 2011;8(6):492-500. doi: 10.7150/ijms.8.492. Epub 2011 Aug 24.
5
Gastric pseudo-signet ring cells: a potential diagnostic pitfall.胃假性印戒细胞：一个潜在的诊断陷阱。
Virchows Arch. 2011 Sep;459(3):347-9. doi: 10.1007/s00428-011-1136-4. Epub 2011 Aug 12.
6
Relationship between single nucleotide polymorphisms and haplotypes in DPYD and toxicity and efficacy of capecitabine in advanced colorectal cancer.DPYD 中单核苷酸多态性与单倍型的关系及其对晚期结直肠癌卡培他滨毒性和疗效的影响。
Clin Cancer Res. 2011 May 15;17(10):3455-68. doi: 10.1158/1078-0432.CCR-10-2209. Epub 2011 Apr 15.
7
Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial.可切除胃食管腺癌的围手术期化疗与单纯手术比较：FNCLCC 和 FFCD 多中心 III 期试验。
J Clin Oncol. 2011 May 1;29(13):1715-21. doi: 10.1200/JCO.2010.33.0597. Epub 2011 Mar 28.
8
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.2008 年全球癌症负担估计值：GLOBOCAN 2008。
Int J Cancer. 2010 Dec 15;127(12):2893-917. doi: 10.1002/ijc.25516.
9
Global cancer statistics.全球癌症统计数据。
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. doi: 10.3322/caac.20107. Epub 2011 Feb 4.
10
Gastric cardiac carcinomas involving the esophagus are more adequately staged as gastric cancers by the 7th edition of the American Joint Commission on Cancer Staging System.涉及食管的胃贲门癌在第 7 版美国癌症联合委员会分期系统中被更恰当地归类为胃癌。
Mod Pathol. 2011 Jan;24(1):138-46. doi: 10.1038/modpathol.2010.183. Epub 2010 Sep 17.
Zotero 插件