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波兰一名患者因匐行恶丝虫感染导致外周血微丝蚴血症加重:病例描述与文献回顾

Dirofilaria repens infection as a cause of intensive peripheral microfilariemia in a Polish patient: process description and cases review.

作者信息

Kłudkowska Matylda, Pielok Łukasz, Frąckowiak Krystyna, Masny Aleksander, Gołąb Elżbieta, Paul Małgorzata

机构信息

Poznań University of Medical Sciences, Department and Clinic of Tropical and Parasitic Diseases, Poznań, Poland.

H. Święcicki University Hospital, Central Laboratory of Microbiology, Division of Parasitology, Poznań, Poland.

出版信息

Acta Parasitol. 2018 Sep 25;63(3):657-663. doi: 10.1515/ap-2018-0077.

Abstract

Dirofilariasis is a parasitic disease of dogs and other carnivores transmitted mainly by the mosquitoes of the genera Culex, Aedes, Anopheles. Full life cycle of the Dirofilaria nematodes in humans is extremely rarely observed, usually lacking species determination at the molecular level. We report fully documented unusual clinical manifestation of subcutaneous dirofilariasis with intensive microfilariemia in peripheral blood revealed by the Knott's concentration technique. The identification of the Dirofilaria repens nematode was based on typical morphological findings for adult gravid female nematode found in the histopathological preparations. The morphology of microfilariae obtained from patient's peripheral blood was also typical for D. repens. The final identification was confirmed by the molecular analysis of microfilariae collected from the blood.

摘要

恶丝虫病是一种主要由库蚊属、伊蚊属、按蚊属蚊子传播的犬类和其他食肉动物的寄生虫病。在人类中极少观察到恶丝虫线虫的完整生命周期,通常在分子水平上缺乏物种鉴定。我们报告了皮下恶丝虫病不寻常的临床表现,通过Knott浓集技术发现外周血中有大量微丝蚴血症。匐行恶丝虫线虫的鉴定基于组织病理学制剂中发现的成年妊娠雌性线虫的典型形态学特征。从患者外周血中获得的微丝蚴形态也具有匐行恶丝虫的典型特征。从血液中收集的微丝蚴的分子分析证实了最终鉴定结果。

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