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一例人类感染的罕见病例报告。

A Rare Case Report of a Human Infection.

作者信息

Schatz Christoph, Füßl Magdalena, Caf Yasemin, Schmitz Katja, Kresse Daniela, Ludwig Wilhelm, Walochnik Julia, Knabl Ludwig

机构信息

Tyrolpath Obrist Brunhuber GmbH, Hauptplatz 4, 6511 Zams, Austria.

University Hospital for Inner Medicine II, Tirol Kliniken, Anichstraße 35, 6020 Innsbruck, Austria.

出版信息

Microorganisms. 2025 Feb 21;13(3):476. doi: 10.3390/microorganisms13030476.

DOI:10.3390/microorganisms13030476
PMID:40142370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11946268/
Abstract

In June 2024, a 41 year-old woman presented to the infectious diseases outpatient clinic with a left inguinal mass progressing in size. The patient had previously been on vacation in Greece. When a tumor was initially suspected, the mass was surgically removed. Staining with Grocott methenamine silver and Alzian blue were inconspicuous, but histopathologic examination revealed a clear histiocytic demarcation, followed by a confirmation of the suspected diagnosis of dirofilariasis caused by by PCR. Even though still a rare event in Austria, the number of human cases has been continuously increasing in recent years. This is partly due to the increased spread of the parasite due to climate change and globalization.

摘要

2024年6月,一名41岁女性因左侧腹股沟肿块增大前往传染病门诊就诊。该患者此前在希腊度假。最初怀疑是肿瘤时,肿块被手术切除。Grocott六胺银染色和阿尔辛蓝染色均不明显,但组织病理学检查显示组织细胞分界清晰,随后通过聚合酶链反应(PCR)确诊为疑似由恶丝虫病引起的诊断。尽管在奥地利这仍然是罕见事件,但近年来人类病例数量一直在持续增加。部分原因是由于气候变化和全球化导致寄生虫传播增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/11946268/213834128b62/microorganisms-13-00476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/11946268/b7bd1a199a06/microorganisms-13-00476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/11946268/213834128b62/microorganisms-13-00476-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/11946268/b7bd1a199a06/microorganisms-13-00476-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2db5/11946268/213834128b62/microorganisms-13-00476-g002.jpg

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本文引用的文献

1
Genetic variability of Dirofilaria repens isolates from humans and dogs in Italy.意大利人体和犬体内的旋盘尾丝虫分离株的遗传变异性。
Vet Parasitol. 2024 Feb;326:110096. doi: 10.1016/j.vetpar.2023.110096. Epub 2023 Dec 12.
2
Microfilaremic Dirofilaria repens Infection in Patient from Serbia.塞尔维亚患者微丝蚴血症的犬恶丝虫感染。
Emerg Infect Dis. 2023 Dec;29(12):2548-2550. doi: 10.3201/eid2912.230796.
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Severe and Rare Case of Human Dirofilaria repens Infection with Pleural and Subcutaneous Manifestations, Slovenia.严重且罕见的人肤蝇蚴感染病例,伴胸膜和皮下表现,斯洛文尼亚。
Emerg Infect Dis. 2022 Dec;28(12):2504-2507. doi: 10.3201/eid2812.221366.
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Estimated specific antibody-based true sero-prevalences of canine filariosis in dogs in Central Europe and the UK.估计中欧和英国犬类丝虫病的特定基于抗体的真实血清流行率。
Parasitol Res. 2022 Dec;121(12):3671-3680. doi: 10.1007/s00436-022-07695-1. Epub 2022 Oct 19.
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Autochthonous Human Dirofilaria repens Infection in Austria.奥地利本土人感染雷蚴丝虫。
Acta Parasitol. 2022 Jun;67(2):1039-1043. doi: 10.1007/s11686-021-00506-0. Epub 2022 Jan 12.
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spp. and : Current Risk of Spreading in Central and Northern Europe.物种及:当前在中欧和北欧传播的风险。
Pathogens. 2021 Oct 1;10(10):1268. doi: 10.3390/pathogens10101268.
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New cases of human dirofilariosis on the Balkan Peninsula - "Masked intruders" uncovered by a surgeon.巴尔干半岛出现人类心丝虫病新病例 - 外科医生揭开“隐形入侵者”的面纱。
Parasitol Int. 2022 Feb;86:102482. doi: 10.1016/j.parint.2021.102482. Epub 2021 Oct 19.
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microfilaremia in humans: Case description and literature review.人类微丝蚴血症:病例描述与文献综述。
One Health. 2021 Aug 12;13:100306. doi: 10.1016/j.onehlt.2021.100306. eCollection 2021 Dec.
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Human dirofilariosis in Austria: the past, the present, the future.奥地利的人犬恶丝虫病:过去、现在和未来。
Parasit Vectors. 2021 Apr 29;14(1):227. doi: 10.1186/s13071-021-04696-4.
10
Subcutaneous nodules and dermatitis associated with non- non dirofilariosis morphologically consistent with in a 2-year-old male domestic cat in Florida, USA.美国佛罗里达州一只2岁雄性家猫身上出现皮下结节和皮炎,形态学上与非恶丝虫病相符。
Vet Q. 2020 Dec;40(1):215-222. doi: 10.1080/01652176.2020.1814972.