Nguyen Anh Thi Nguyet, Nishijo Muneko, Pham Tai The, Tran Nghi Ngoc, Tran Anh Hai, Hoang Luong Van, Boda Hitomi, Morikawa Yuko, Nishino Yoshikazu, Nishijo Hisao
Department of Public Health and Epidemiology, Kanazawa Medical University, 1-1, Daigaku, Uchinada, Ishikawa, 920-0293, Japan.
Biomedical and Pharmaceutical Research Center, Vietnam Military Medical University, Ha Noi, Vietnam.
BMC Pediatr. 2018 Jul 5;18(1):213. doi: 10.1186/s12887-018-1171-2.
We previously reported that perinatal dioxin exposure increased autistic traits in children living in dioxin-contaminated areas of Vietnam. In the present study, we investigated the impact of dioxin exposure on children's eating behavior, which is often altered in those with developmental disorders.
A total of 185 mother-and-child pairs previously enrolled in a birth cohort in dioxin-contaminated areas participated in this survey, conducted when the children reached 3 years of age. Perinatal dioxin exposure levels in the children were estimated using dioxin levels in maternal breast milk after birth. Mothers were interviewed using the Children's Eating Behaviour Questionnaire (CEBQ). A multiple linear regression model was used to analyze the association between dioxin exposure and CEBQ scores, after controlling for covariates such as location, parity, maternal age, maternal education, maternal body mass index, family income, children's gestational age at delivery, and children's age at the time of the survey. A general linear model was used to analyze the effects of sex and dioxin exposure on CEBQ scores.
There was no significant association between most dioxin congeners or toxic equivalencies of polychlorinated dibenzo-p-dioxins/furans (TEQ-PCDDs/Fs) and CEBQ scores in boys, although significant associations between some eating behavior sub-scores and 1,2,3,4,6,7,8,9-octachlorodibenzofuran were observed. In girls, there was a significant inverse association between levels of TEQ-PCDFs and enjoyment of food scores and between levels of TEQ-PCDFs and TEQ-PCDDs/Fs and desire to drink scores. Two pentachlorodibenzofuran congeners and 1,2,3,6,7,8-hexachlorodibenzofuran were associated with a decreased enjoyment of food score, and seven PCDF congeners were associated with a decreased desire to drink score. The adjusted mean enjoyment of food score was significantly lower in children of both sexes exposed to high levels of TEQ-PCDFs. There was, however, a significant interaction between sex and TEQ-PCDF exposure in their effect on desire to drink scores, especially in girls.
Perinatal exposure to dioxin can influence eating behavior in children and particularly in girls. A longer follow-up study would be required to assess whether emotional development that affects eating styles and behaviors is related to dioxin exposure.
我们之前报道过，越南受二噁英污染地区的围产期二噁英暴露会增加儿童的自闭症特征。在本研究中，我们调查了二噁英暴露对儿童饮食行为的影响，饮食行为在发育障碍儿童中通常会发生改变。
共有185对母婴参与了本次调查，他们之前被纳入了一个位于二噁英污染地区的出生队列，调查在儿童3岁时进行。利用出生后母乳中的二噁英水平来估计儿童的围产期二噁英暴露水平。使用儿童饮食行为问卷（CEBQ）对母亲进行访谈。在控制了诸如地点、产次、母亲年龄、母亲教育程度、母亲体重指数、家庭收入、儿童出生时的孕周以及调查时儿童的年龄等协变量之后，使用多元线性回归模型来分析二噁英暴露与CEBQ评分之间的关联。使用一般线性模型来分析性别和二噁英暴露对CEBQ评分的影响。
在男孩中，大多数二噁英同系物或多氯二苯并对二噁英/呋喃的毒性当量（TEQ - PCDDs/Fs）与CEBQ评分之间没有显著关联，不过在一些饮食行为子评分与1,2,3,4,6,7,8,9 - 八氯二苯并呋喃之间观察到了显著关联。在女孩中，TEQ - PCDFs水平与食物享受评分之间以及TEQ - PCDFs水平与TEQ - PCDDs/Fs水平与饮水欲望评分之间存在显著的负相关。两种五氯二苯并呋喃同系物和1,2,3,6,7,8 - 六氯二苯并呋喃与食物享受评分降低有关，七种PCDF同系物与饮水欲望评分降低有关。暴露于高水平TEQ - PCDFs的男女儿童的食物享受评分调整均值显著较低。然而，在性别和TEQ - PCDF暴露对饮水欲望评分的影响方面存在显著的交互作用，尤其是在女孩中。
围产期二噁英暴露会影响儿童尤其是女孩的饮食行为。需要进行更长时间的随访研究来评估影响饮食方式和行为的情绪发展是否与二噁英暴露有关。
