老年斑中谷氨酸脱羧酶样免疫反应性神经突
Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques.
作者信息
Walker L C, Kitt C A, Struble R G, Schmechel D E, Oertel W H, Cork L C, Price D L
出版信息
Neurosci Lett. 1985 Aug 30;59(2):165-9. doi: 10.1016/0304-3940(85)90194-6.
PMID:2997667
Abstract
In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that gamma-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.
摘要
在一只26岁老龄恒河猴的新皮层中，一些老年斑（由淀粉样蛋白的存在定义）内的一小部分异常神经突对谷氨酸脱羧酶呈免疫反应阳性。这表明γ-氨基丁酸合成神经元可能参与了老年大脑中斑块的形成。
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