School of Paediatrics and Reproductive Health, and Robinson Research Institute, University of Adelaide, Adelaide 5006, Australia.
School of Public Health, University of Adelaide, Adelaide 5006, Australia.
Nutrients. 2018 Jul 5;10(7):870. doi: 10.3390/nu10070870.
The aim of our study was to evaluate associations between maternal dietary factors and fetal growth and adiposity in overweight and obese women. Women randomised to the ‘Standard Care’ group of the LIMIT trial were included. Maternal dietary factors including Healthy Eating Index, total energy, fat, carbohydrates, protein, glycaemic load and index were measured using the Harvard semi-quantitative Food Frequency questionnaire at time of study entry, 28 and 36 weeks’ gestation. Fetal ultrasound measurements of biometry and adiposity were obtained at 28 and 36 weeks’ gestation. Linear regression models were used to associate between dietary factors and fetal growth and adiposity measurements. There were 721 women included in this exploratory analysis. A 10 unit increase in the log total energy was associated with a reduction in mid-thigh lean mass by 4.94 mm at 28 weeks (95% CI −9.57 mm, −0.32 mm; = 0.036) and 7.02 mm at 36 weeks (95% CI −13.69 mm, −0.35 mm; = 0.039). A 10 unit increase in Healthy Eating Index score was associated with a reduced mean subscapular skin fold measure at 28 weeks by 0.17 mm (95% CI −0.32 mm, −0.03 mm; = 0.021). We did not identify consistent associations between maternal diet and measures of fetal growth and adiposity in overweight and obese women.
我们的研究目的是评估超重和肥胖女性的母体饮食因素与胎儿生长和肥胖之间的关联。本研究纳入了 LIMIT 试验中随机分配至“标准护理”组的女性。在研究入组时、妊娠 28 周和 36 周时，采用哈佛半定量食物频率问卷评估母体饮食因素，包括健康饮食指数、总能量、脂肪、碳水化合物、蛋白质、血糖负荷和指数。在妊娠 28 周和 36 周时，通过胎儿超声测量生物测量和肥胖度。采用线性回归模型将饮食因素与胎儿生长和肥胖度测量结果进行关联。本探索性分析共纳入 721 名女性。总能量每增加 10 个单位，28 周时大腿中段瘦组织量减少 4.94 毫米（95%CI：−9.57 毫米，−0.32 毫米； = 0.036），36 周时减少 7.02 毫米（95%CI：−13.69 毫米，−0.35 毫米； = 0.039）。健康饮食指数每增加 10 个单位，28 周时肩胛下角皮褶厚度的平均值减少 0.17 毫米（95%CI：−0.32 毫米，−0.03 毫米； = 0.021）。我们没有发现超重和肥胖女性的母体饮食与胎儿生长和肥胖度测量结果之间存在一致的关联。
