School of Applied Sciences, University of Campinas, Limeira, SP 13484-350, Brazil.
Faculty of Food Engineering-FEA, Department of Food and Nutrition-DEPAN, University of Campinas, Campinas, SP 13484-350, Brazil.
Nutrients. 2018 Jul 5;10(7):872. doi: 10.3390/nu10070872.
Some flavonoids identified in beet stalks can help the antioxidant endogenous defenses during a chronic inflammation process. The current study investigates the effect of polyphenols present in beet stalks and leaves on liver oxidative damage in mice fed a high-fat diet (HF). The control (CT) or HF diet groups were supplemented with dehydrated beet stalks and leaves (SL) or beet stalk and leaf ethanolic extract (EX). In terms of Vitexin-rhaminoside equivalents (VRE), EX groups received ~5.91 mg of VRE·100 g diet, while the SL groups received ~3.07 mg VRE·100 g diet. After 8 weeks, we evaluated fasting blood glucose; cholesterol, hepatic Malondialdehyde (MDA) levels and hepatic Glutathione (GSH), Glutathione peroxidase (GPx), Glutathione reductase (GR) and Superoxide dismutase (SOD) activity. Dehydrated beet stalks and leaves (HFSL) attenuated the deleterious effects of a HF diet on lipid metabolism, reduced fasting blood glucose levels, ameliorated cholesterol levels and reduced GPx and GR activities ( < 0.05) compared to the HF group. However; the addition of ethanolic extract from beet stalks and leaves was unable ( > 0.05) to prevent the liver damage caused by HF diet in mice. The presence of flavonoids, such as Vitexin derivatives in beet stalks and leaves can help the liver damage induced by HF diet.
一些在甜菜茎中发现的类黄酮可以帮助抗氧化内在防御在慢性炎症过程中。本研究调查了存在于甜菜茎和叶中的多酚对高脂肪饮食（HF）喂养小鼠肝脏氧化损伤的影响。对照组（CT）或 HF 饮食组补充脱水甜菜茎和叶（SL）或甜菜茎和叶乙醇提取物（EX）。就牡荆素鼠李糖苷当量（VRE）而言，EX 组接受了5.91mg 的 VRE·100g 饮食，而 SL 组接受了3.07mg 的 VRE·100g 饮食。8 周后，我们评估了空腹血糖；胆固醇，肝丙二醛（MDA）水平和肝谷胱甘肽（GSH），谷胱甘肽过氧化物酶（GPx），谷胱甘肽还原酶（GR）和超氧化物歧化酶（SOD）活性。脱水甜菜茎和叶（HFSL）减轻了 HF 饮食对脂质代谢的有害影响，降低了空腹血糖水平，改善了胆固醇水平并降低了 GPx 和 GR 活性（<0.05）与 HF 组相比。然而；添加甜菜茎和叶的乙醇提取物（>0.05）无法预防 HF 饮食引起的小鼠肝脏损伤。存在于甜菜茎和叶中的类黄酮，如牡荆素衍生物可以帮助减轻 HF 饮食引起的肝脏损伤。
