Peniazaphilin A，一种由青霉属 CPCC 400786 产生的新型氮杂菲酮衍生物。
Peniazaphilin A, a new azaphilone derivative produced by Penicillium sp. CPCC 400786.
机构信息
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
J Antibiot (Tokyo). 2018 Oct;71(10):905-907. doi: 10.1038/s41429-018-0077-4. Epub 2018 Jul 5.
A new azaphilone derivative, named peniazaphilin A (1) and one known isocoumarin, (R)-3-methyl-6-hydroxy-8-methoxy-3,4-dihydroisocoumarin (2) were isolated from the fungus Penicillium sp. CPCC 400786. Their structures were elucidated by means of extensive spectroscopic analysis. The absolute configuration of 2 was established by circular dichroism for the first time. Compounds 1 and 2 exhibited weak anti-HIV activities with the IC values of 60.4 and 69.3 μM, respectively.
从真菌青霉 CPCC 400786 中分离得到一个新的氮杂菲酮衍生物，命名为 peniazaphilin A（1）和一个已知的异香豆素（R）-3-甲基-6-羟基-8-甲氧基-3,4-二氢异香豆素（2）。通过广泛的光谱分析阐明了它们的结构。（2）的绝对构型首次通过圆二色谱确定。化合物 1 和 2 表现出微弱的抗 HIV 活性，IC 值分别为 60.4 和 69.3 μM。
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