Shaanxi Engineering Center of Bioresource Chemistry and Sustainable Utilization, College of Science, Northwest A&F University, Yangling, China.
Chirality. 2012 Aug;24(8):621-7. doi: 10.1002/chir.22044. Epub 2012 Jun 7.
A new azaphilone derivative, named fusarone (1), has been isolated from the ethyl acetate soluble extract of the fermentation broth of an endophytic fungus, Fusarium sp. LN-12, isolated from the leaves of Melia azedarach Linn. The structure of the new compound was established on the basis of extensive spectroscopic analysis, including 1D-NMR and 2D-NMR ((1) H-(1)H COSY, TOCSY, HSQC, HMBC, and NOESY) experiments. The absolute configurations of fusarone (1) and of a second related azaphilone were determined by means of electronic circular dichroism spectroscopy and optical rotation calculations.
从内生真菌 Fusarium sp. LN-12 的发酵液的乙酸乙酯可溶部分中分离得到了一种新的薁类衍生物，命名为呋莎酮（1）。该内生真菌是从苦楝树的叶子中分离得到的。新化合物的结构是基于广泛的光谱分析确定的，包括 1D-NMR 和 2D-NMR（1H-1H COSY、TOCSY、HSQC、HMBC 和 NOESY）实验。通过电子圆二色光谱和旋光计算确定了呋莎酮（1）和第二个相关薁类的绝对构型。
