NTproBNP 作为支气管肺发育不良早产儿肺动脉高压早期筛查的替代生物标志物。
NTproBNP as a surrogate biomarker for early screening of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia.
机构信息
Department of Pediatric Cardiology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Department of Pediatric Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
出版信息
J Perinatol. 2018 Sep;38(9):1252-1257. doi: 10.1038/s41372-018-0164-1. Epub 2018 Jul 6.
OBJECTIVE
Pulmonary hypertension (PH) is a known complication of bronchopulmonary dysplasia (BPD). This study aimed to determine the utility of serial N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) levels in the screening of BPD associated PH (BPD-PH) in preterm infants.
STUDY DESIGN
Infants with birth weight <1500 g and <30 week corrected gestational age (CGA) were followed with serial NTproBNP levels and echocardiograms (ECHO). They were divided into control, BPD and BPD-PH groups. Statistical analyses included repeated measures analysis of variance and receiver operator curve (ROC) generation.
RESULTS
Infants in the BPD-PH and BPD group had significantly elevated NTproBNP levels as compared to the control group. ROC curves for NTproBNP at 28 weeks CGA provided a cut-point of 2329 pg/ml and 578.1 pg/ml for detection of BPD-PH and BPD, respectively.
CONCLUSIONS
NTproBNP appears to be a good screening tool to determine the onset of BPD-PH as early as 28 weeks CGA.
目的
肺动脉高压（PH）是支气管肺发育不良（BPD）的已知并发症。本研究旨在确定连续测定 N 端脑利钠肽前体（NTproBNP）水平在筛查早产儿支气管肺发育不良相关肺动脉高压（BPD-PH）中的作用。
研究设计
对出生体重<1500g 和<30 周校正胎龄（CGA）的婴儿进行连续 NTproBNP 水平和超声心动图（ECHO）检查。他们被分为对照组、BPD 组和 BPD-PH 组。统计分析包括重复测量方差分析和接收者操作曲线（ROC）生成。
结果
与对照组相比，BPD-PH 组和 BPD 组的 NTproBNP 水平显著升高。28 周 CGA 时 NTproBNP 的 ROC 曲线分别为 2329pg/ml 和 578.1pg/ml，用于检测 BPD-PH 和 BPD。
结论
NTproBNP 似乎是一种很好的筛查工具，可在 28 周 CGA 时早期确定 BPD-PH 的发生。
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