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精准医学在前列腺癌中的应用。

Precision medicine applications in prostate cancer.

作者信息

McCrea Edel M, Lee Daniel K, Sissung Tristan M, Figg William D

机构信息

Molecular Pharmacology Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Medical Oncology Service, and the Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

出版信息

Ther Adv Med Oncol. 2018 Jun 18;10:1758835918776920. doi: 10.1177/1758835918776920. eCollection 2018.

DOI:10.1177/1758835918776920
PMID:29977347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6024288/
Abstract

Aided by developments in diagnostics and therapeutics, healthcare is increasingly moving toward precision medicine, in which treatment is customized to each individual. We discuss the relevance of precision medicine in prostate cancer, including gene targets, therapeutics and resistance mechanisms. We foresee precision medicine becoming an integral component of prostate cancer management to increase response to therapy and prolong survival.

摘要

在诊断和治疗技术发展的推动下,医疗保健正日益朝着精准医学的方向发展,即针对每个个体定制治疗方案。我们讨论了精准医学在前列腺癌中的相关性,包括基因靶点、治疗方法和耐药机制。我们预计精准医学将成为前列腺癌管理的一个不可或缺的组成部分,以提高治疗反应并延长生存期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f0b/6024288/6ba89c8eeb2a/10.1177_1758835918776920-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f0b/6024288/6ba89c8eeb2a/10.1177_1758835918776920-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3f0b/6024288/6ba89c8eeb2a/10.1177_1758835918776920-fig1.jpg

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Exp Biol Med (Maywood). 2018 Feb;243(3):308-312. doi: 10.1177/1535370217740861. Epub 2017 Nov 6.
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Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF.PSF 通过调控剪接体基因表达在晚期前列腺癌中发挥作用。
Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):10461-10466. doi: 10.1073/pnas.1706076114. Epub 2017 Sep 11.
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Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer.
前列腺癌综述:遗传学、诊断、治疗选择和替代方法。
Molecules. 2022 Sep 5;27(17):5730. doi: 10.3390/molecules27175730.
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Cureus. 2022 Jul 15;14(7):e26881. doi: 10.7759/cureus.26881. eCollection 2022 Jul.
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Initial Institutional Experience with 18F-Fluciclovine PET-CT in Biochemical Recurrence of Prostate Cancer.18F-氟丁氨酸 PET-CT 在前列腺癌生化复发中的初步机构经验。
South Med J. 2021 Nov;114(11):703-707. doi: 10.14423/SMJ.0000000000001314.
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A Narrative Review of Implementing Precision Oncology in Metastatic Castration-Resistant Prostate Cancer in Emerging Countries.新兴国家转移性去势抵抗性前列腺癌中实施精准肿瘤学的叙述性综述
Oncol Ther. 2021 Dec;9(2):311-327. doi: 10.1007/s40487-021-00160-6. Epub 2021 Jul 8.
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