Findakly Dawood, Duong Tony, Shimon Tim, Wang Jue
Hematology and Medical Oncology, Feist-Weiller Cancer Center, Louisiana State University Health Shreveport, Shreveport, USA.
Internal Medicine, University of Arizona College of Medicine, Phoenix, USA.
Cureus. 2022 Jul 15;14(7):e26881. doi: 10.7759/cureus.26881. eCollection 2022 Jul.
Although significant advances in the treatment of prostate cancer (PC) have recently been made, the treatment of metastatic liver disease remains challenging. Recent advances have led to multiple novel therapies and multi-treatment approaches combining systemic and locoregional modalities, such as thermal ablation, representing a promising strategy that has received attention in recent years. Nevertheless, no standard locoregional treatment regimens exist for the management of liver metastases of PC. In addition, regional therapy alone is unlikely to provide durable cancer control. Here, we report for the first time a successful treatment of hepatic metastases of PC using stereotactic image-guided percutaneous microwave ablation and the poly (ADP-ribose) polymerase-1 inhibitor, olaparib.
尽管近年来前列腺癌（PC）的治疗取得了重大进展，但转移性肝病的治疗仍然具有挑战性。最近的进展带来了多种新型疗法以及将全身和局部区域治疗方式相结合的多治疗方法，例如热消融，这是一种近年来受到关注的有前景的策略。然而，目前尚无用于管理PC肝转移的标准局部区域治疗方案。此外，单纯的区域治疗不太可能实现持久的癌症控制。在此，我们首次报告了使用立体定向图像引导经皮微波消融和聚（ADP-核糖）聚合酶-1抑制剂奥拉帕尼成功治疗PC肝转移的病例。
