血清总IgE水平与年龄相关性白内障的J形关联。
The J-shape association of serum total IgE levels with age-related cataract.
作者信息
Park Sangshin, Choi Nam-Kyong
机构信息
Center for International Health Research, Rhode Island Hospital, the Warren Alpert Medical School of Brown University, Providence 02912, RI, USA.
Department of Pediatrics, the Warren Alpert Medical School of Brown University, Providence 02912, RI, USA.
出版信息
Int J Ophthalmol. 2018 Jun 18;11(6):1009-1012. doi: 10.18240/ijo.2018.06.19. eCollection 2018.
AIM
To address the association between serum total IgE levels and age-related cataract in adults.
METHODS
The study participants consisted of 1052 adults aged 40y or older in the Korean National Health and Nutrition Examination Survey 2010. We performed multivariable logistic regression analyses using the quartile cut-points of total IgE levels.
RESULTS
The odds ratios (ORs) for nuclear and any cataract with ≥267 kU/L of serum IgE levels were 1.75 [95% confidence intervals (CI), 1.04-2.96] and 2.00 (95%CI, 1.22-3.27), respectively, comparing to 35-87 kU/L. Interestingly, participants with ≤35 kU/L of IgE levels (OR, 1.67; 95%CI, 1.02-2.72) also had higher risk for any cataract than those with 35-87 kU/L. The risk for any cataract (OR, 1.48; 95%CI, 1.03-2.13) was higher in participants with high total IgE levels (>150 kU/L), comparing to normal participants.
CONCLUSION
Our findings indicate a J-shaped relationship between serum IgE levels and age-related cataract.
目的
探讨成人血清总IgE水平与年龄相关性白内障之间的关联。
方法
研究对象为2010年韩国国民健康与营养检查调查中1052名40岁及以上的成年人。我们使用总IgE水平的四分位数切点进行多变量逻辑回归分析。
结果
血清IgE水平≥267 kU/L时，核性白内障和任何类型白内障的优势比（OR）分别为1.75 [95%置信区间（CI），1.04 - 2.96]和2.00（95%CI，1.22 - 3.27），与35 - 87 kU/L相比。有趣的是，IgE水平≤35 kU/L的参与者（OR，1.67；95%CI，1.02 - 2.72）患任何类型白内障的风险也高于IgE水平为35 - 87 kU/L的参与者。与正常参与者相比，总IgE水平高（>150 kU/L）的参与者患任何类型白内障的风险更高（OR，1.48；95%CI，1.03 - 2.13）。
结论
我们的研究结果表明血清IgE水平与年龄相关性白内障之间呈J形关系。
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