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儿童特应性皮炎、皮肤类固醇与白内障:两例病例报告

Atopic dermatitis, cutaneous steroids and cataracts in children: two case reports.

作者信息

Tatham Andrew

机构信息

Leicester Royal Infirmary, Infirmary Square, Leicester, UK.

出版信息

J Med Case Rep. 2008 Apr 28;2:124. doi: 10.1186/1752-1947-2-124.

Abstract

INTRODUCTION

Atopic dermatitis is a chronic, pruritic, eczematous skin disease mediated through an immediate (type I) hypersensitivity reaction. Posterior sub-capsular cataracts are a recognised complication of atopic dermatitis in adults; however they are rare in children. The management of atopic dermatitis is based on the exclusion of allergens, the use of emollients, and on topical corticosteroids for disease exacerbations. Cataracts may be due to atopic dermatitis but may also occur secondary to the use of corticosteroids.

CASE PRESENTATION

We describe two children with atopic dermatitis, treated with cutaneous corticosteroids, both of whom were diagnosed with bilateral posterior sub-capsular cataracts.

CONCLUSION

These cases demonstrate that atopic dermatitis and topical corticosteroids may be associated with cataracts in children as well as adults. The cause of cataracts in atopic dermatitis is not known, however, it has been suggested that habitual tapping and rubbing of the face may play a role. Care needs to be taken when prescribing corticosteroids. Inadequate treatment of atopic dermatitis may lead to other ocular complications such as keratitis and permanent visual loss.

摘要

引言

特应性皮炎是一种通过速发型(I 型)超敏反应介导的慢性、瘙痒性、湿疹性皮肤病。后囊下白内障是成人特应性皮炎公认的并发症;然而在儿童中较为罕见。特应性皮炎的治疗基于排除过敏原、使用润肤剂以及在疾病加重时使用外用皮质类固醇。白内障可能由特应性皮炎引起,但也可能继发于皮质类固醇的使用。

病例报告

我们描述了两名患有特应性皮炎并接受皮肤皮质类固醇治疗的儿童,他们均被诊断为双侧后囊下白内障。

结论

这些病例表明,特应性皮炎和外用皮质类固醇在儿童以及成人中都可能与白内障有关。特应性皮炎中白内障的病因尚不清楚,然而,有人认为习惯性地轻拍和摩擦面部可能起了一定作用。在开具皮质类固醇药物时需谨慎。特应性皮炎治疗不当可能导致其他眼部并发症,如角膜炎和永久性视力丧失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5700/2383898/a2e36c2fd7d3/1752-1947-2-124-1.jpg

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