Velasquez Diego, Chaunier Laurent, Guessasma Sofiane, Faure Frédéric, Bizeau Alain, Pavon-Djavid Graciela, Meddahi-Pellé Anne, Lourdin Denis
INRA, UR1268 Biopolymères Interactions Assemblages, Rue de la Géraudière, Nantes, 44316, France.
Ingennova Research Group, CES University. Calle 10A # 22 - 04. Medellín, Colombia.
Bioimpacts. 2018;8(2):91-98. doi: 10.15171/bi.2018.11. Epub 2017 Jan 14.
Starch-based materials were designed using a special extrusion die in order to obtain a tube-shaped device for application to salivary duct treatment in the field of endoscopy, i.e., sialendoscopy . Extrusion process was used to produce starch tubes. Mechanical properties of the dry tube before implantation were determined using an axial compression test. A finite element study was carried out to simulate the behavior of the hydrated tube under external axial pressure. Hydrolysis of these devices in a simulated salivary solution was studied, as well as its glycerol kinetics release. An animal short-term implantation model for salivary ducts was proposed as a feasibility study for starch tube-shaped devices. A continuous production of regular and size-controlled tubes was obtained. The very small diameter obtained, less than 2 mm, corresponds to the requirement of being insertable in a human salivary duct using sialendoscopy guidewire. Finite element analysis showed that the starch tube can still support an external pressure higher than 0.2 MPa without irreversible damage. After 4 days of implantation, the host response is encouraging and the inflammatory response for this type of procedure remains normal. These devices were adapted to sialendoscopic guidewires and able to be implanted in the salivary ducts of pigs. If a longer lasting tube is required, the crystallinity of the starch material should be improved.
基于淀粉的材料是使用特殊的挤出模具设计的，目的是获得一种管状装置，用于在内窥镜领域，即唾液腺内窥镜检查中应用于唾液导管治疗。采用挤出工艺生产淀粉管。使用轴向压缩试验测定植入前干燥管的机械性能。进行了有限元研究，以模拟水合管在外部轴向压力下的行为。研究了这些装置在模拟唾液溶液中的水解情况及其甘油动力学释放。提出了一种唾液导管动物短期植入模型，作为淀粉管状装置的可行性研究。获得了连续生产的规则且尺寸可控的管子。所获得的非常小的直径，小于2毫米，符合使用唾液腺内窥镜导丝插入人体唾液导管的要求。有限元分析表明，淀粉管在外部压力高于0.2 MPa时仍能承受而不会造成不可逆损伤。植入4天后，宿主反应令人鼓舞，此类手术的炎症反应保持正常。这些装置适用于唾液腺内窥镜导丝，能够植入猪的唾液导管中。如果需要更持久的管子，则应提高淀粉材料的结晶度。
