INRA, UR1268 Biopolymères Interactions Assemblages, Rue de la Géraudière, 44316 Nantes, France.
INSERM, U1148, Université Paris 13, Université Paris7, Sorbonne Paris Cité LVTS, 46, rue Henri Huchard, 75877 Paris, France.
Carbohydr Polym. 2015 Jun 25;124:180-7. doi: 10.1016/j.carbpol.2015.02.006. Epub 2015 Feb 12.
The application of starch-based materials for biomedical purposes has attracted significant interest due to their biocompatibility. The physical properties and crystal structure of materials based on potato starch (PS) and amylomaize starch (AMS) were studied under physiological conditions. PS plasticized with 20% glycerol presented the best mechanical properties with an elastic modulus of 1.6MPa and a weak swelling, remaining stable for 30 days. The in vitro cell viability of 3T3 cells after contact with extracts from PS and AMS with 20% glycerol is 72% and 80%, respectively. PS presented good tissue integration and no significant inflammation or foreign body response after 30 days intra-muscular implantation in a rat model, contrary to AMS. It was shown that glycerol plasticization favors a fast B-type crystallization of PS materials, enhancing their mechanical strength and durability, and making them a good candidate for bioresorbable and biocompatible materials for implantable medical devices.
基于淀粉的材料在生物医学方面的应用因其生物相容性而引起了极大的关注。本文研究了在生理条件下基于马铃薯淀粉（PS）和蜡质玉米淀粉（AMS）的材料的物理性质和晶体结构。20%甘油增塑的 PS 具有最佳的机械性能，弹性模量为 1.6MPa，溶胀性弱，在 30 天内保持稳定。与含有 20%甘油的 PS 和 AMS 提取物接触的 3T3 细胞的体外细胞活力分别为 72%和 80%。在大鼠模型中进行 30 天的肌肉内植入后，PS 表现出良好的组织整合，没有明显的炎症或异物反应，而 AMS 则相反。结果表明，甘油增塑有利于 PS 材料快速形成 B 型结晶，提高其机械强度和耐久性，使其成为可生物吸收和生物相容的植入式医疗器械材料的良好候选材料。
