Urology Department, Third Affiliated Hospital of Soochow University, Changzhou 213003, China.
J Immunol Res. 2018 Jun 6;2018:5251801. doi: 10.1155/2018/5251801. eCollection 2018.
Antibody-mediated rejection (ABMR) of renal allograft lacks typical phenotypes and clinical manifestations, always resulting in delayed diagnosis and treatment. It has been considered to be an elemental factor influencing the improvement of the long-term outcome of renal allograft. The B cell activating factor (BAFF) signal plays a fundamental function in the process of antibody-mediated immune response. Data from recipients and the nonhuman primate ABMR model suggest that the BAFF signal participates in the ABMR of renal allograft, while there are objections. The challenges in the diagnosis of ABMR, different study population, and details of research may explain the discrepancy. Large quantities of dynamic, credible data of BAFF ligands and their association with renal allograft pathological characteristics would constitute a direct proof of the role of BAFF in the progression of renal allograft ABMR.
抗体介导的肾移植排斥反应（ABMR）缺乏典型的表型和临床表现，常导致诊断和治疗的延误。它被认为是影响肾移植长期预后改善的基本因素。B 细胞激活因子（BAFF）信号在抗体介导的免疫反应过程中起着基本作用。来自受者和非人类灵长类 ABMR 模型的数据表明，BAFF 信号参与了肾移植的 ABMR，但也存在反对意见。ABMR 诊断的挑战、不同的研究人群和研究细节可能解释了这种差异。大量动态、可信的 BAFF 配体数据及其与肾移植病理特征的关联将构成 BAFF 在肾移植 ABMR 进展中作用的直接证据。
