Ortiz R, Armario A, Castellanos J M, Balasch J
Physiol Behav. 1985 Jun;34(6):857-60. doi: 10.1016/0031-9384(85)90003-4.
The effect of various population densities on corticoadrenal function was studied in prepuberal male mice. High population densities decreased body weight gain. Neither adrenal weight nor basal serum corticosterone were modified by crowding. However, corticoadrenal response to some acute stresses such as noise and forced swimming was higher in crowded mice. As corticoadrenal response to adrenocorticotropin remained unaffected, it appears that crowding induced pituitary-adrenal hyperreactivity. Neither the defecation rate nor exploratory activity were altered by crowding, suggesting a dissociation between pituitary-adrenal responsiveness and behavioral measures presumably related to emotional arousal. These discrepancies may possibly be due to the higher sensitivity of corticoadrenal function to environmental changes. Our results suggest that crowding would be suitable as a model for chronic continuous stress.
在青春期前雄性小鼠中研究了不同种群密度对皮质肾上腺功能的影响。高种群密度降低了体重增加。拥挤对肾上腺重量和基础血清皮质酮均无影响。然而，拥挤小鼠对一些急性应激（如噪音和强迫游泳）的皮质肾上腺反应更高。由于对促肾上腺皮质激素的皮质肾上腺反应未受影响，似乎拥挤诱导了垂体-肾上腺反应性增强。拥挤既未改变排便率也未改变探索活动，这表明垂体-肾上腺反应性与可能与情绪唤醒相关的行为指标之间存在分离。这些差异可能是由于皮质肾上腺功能对环境变化的敏感性较高。我们的结果表明，拥挤适合作为慢性持续应激的模型。
