Andrews J S, Sahgal A
Physiol Behav. 1985 Jul;35(1):93-7. doi: 10.1016/0031-9384(85)90177-5.
We report the effects of intracerebroventricular (ICV) administration of thyrotropin releasing hormone (TRH), a TRH metabolite histidyl-proline diketopiperazine (DKP) and systemically administered d-amphetamine (AMP) on the locomotor activity of two groups of rats which had previously received bilateral injections of either 6-hydroxydopamine (6-OHDA) or saline into the nucleus accumbens. Both TRH and AMP enhanced locomotor activity in control, but not lesioned animals, whereas DKP had very little effect. In a second experiment, the effects of ICV administration of saline, TRH and DKP were tested on rotational behaviour in rats with unilateral lesions of the substantia nigra. Neither peptide induced significant circling on its own. However, coadministration of TRH or DKP with systemically administered AMP enhanced rotation above that found after injection of AMP alone. These results suggest that TRH can act on mesolimbic and nigrostriatal dopamine systems, either directly or by modulating the effects of other dopaminergic agents.
我们报告了向两组大鼠脑室内（ICV）注射促甲状腺激素释放激素（TRH）、TRH的一种代谢产物组氨酰-脯氨酸二酮哌嗪（DKP）以及全身注射右旋苯丙胺（AMP）对其运动活性的影响。这两组大鼠先前已在伏隔核双侧注射了6-羟基多巴胺（6-OHDA）或生理盐水。TRH和AMP均增强了对照组而非损伤组动物的运动活性，而DKP的作用很小。在第二个实验中，测试了向黑质单侧损伤的大鼠脑室内注射生理盐水、TRH和DKP对其旋转行为的影响。单独使用这两种肽均未引起明显的旋转。然而，将TRH或DKP与全身注射的AMP共同给药时，其引起的旋转比单独注射AMP后更明显。这些结果表明，TRH可直接作用于中脑边缘和黑质纹状体多巴胺系统，或通过调节其他多巴胺能药物的作用来发挥作用。
